言语训练联合美金刚治疗脑卒中后失语的有效性和安全性评价

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Abstract Objective: To evaluate the efficacy and safety of speech training combined with memantine in the treatment of post-stroke aphasia (PSA). Methods: A total of 120 patients with PSA, including 60 cases in the control group, 60 cases in the observation group. Both groups were given speech training. The observation group was treated with memantine additionally. The patients in the two groups were evaluated by MMSE and CRRCAE before treatment and 1 and 3 months after treatment. The scores of the two groups were compared and the adverse reactions were observed at the same time. Results: After 3 months of treatment, the MMSE score in the observation group was significantly higher than before (P<0.05). After 1 month of treatment, the scores of listening comprehension and retelling in the observation group and the control group were significantly higher than those before treatment (P<0.05). There was no significant difference in the CRRCAE score between the observation group and the control group (P>0.05). After 3 months of treatment, the CRRCAE score in the observation group and the control group were significantly higher than those before treatment (P<0.05). The improvement of listening comprehension of nouns and sentences in the observation group was significantly better than that in the control group (P<0.05). No obvious adverse reactions were found in both groups. Conclusion: Speech training is effective in improving the language function of PSA patients, and maybe more effective when combined with memantine, especially in noun listening comprehension, sentence listening, and has a higher security.

Key words： post-stroke aphasia memantine speech training minimental state examination

Received: 10 July 2018

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	PAN Rongrong
	HE Jincai

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2018/V48/I11/842

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