重复测量分析左心房最小容积与最大容积在评价蒽环类药物所致心脏毒性中的应用价值

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Abstract Objective: To investigate the value of left atrial minimum volume and left atrial maximum volume by three-dimensional echocardiography (3DE) in evaluating anthracycline-induced cardiotoxity in breast cancer patients receiving chemotherapy. Methods: The study consisted of 53 patients who were diagnosed as breast cancer and then underwent doxorubicin chemotherapy after right breast mastectomy. Conventional echocardiographic parameters including left atrial diameters, ratio of early (E) by Doppler recordings from mitral inflow and peak early diastolic velocity (e’) of lateral mitral annulus by tissue Doppler imaging (E/e’) were performed at baseline and after every cycle of chemotherapy. Left atrial volume parameters including left atrial volume maximum index (LAVmax), left atrial minimum volume index (LAVmin), left atrial ejection volume (LASV), left atrial expansion index (LAEI) were obtained at the same time by 3DE. The above parameters were compared between baseline and after every cycles. Results: Compared with baseline, E/e’ had statistical difference after second to fourth cycle (P<0.05). There were no significant changes in E/e’ after the first chemotherapy (P>0.05). Compared with baseline, conventional echocardiography parameters had no statistically changes. There were statistical differences in LAVmin after every cycle of chemotherapy and in LAVmax after T2, T3 and T4. There was no statistical difference in LASV, LAEI after every cycle of chemotherapy (P>0.05). There were significant correlations between LAVmin, LAVmax and E/e’(P<0.01), with correlation coefficients being 0.677 and 0.603 respectively. Conclusion: LAVmax and LAVmin are better parameters in monitoring anthracycline chemotherapy-associated cardiotoxicity and have significant correlations with diastolic function of the left ventricle.

Key words： left atrial minimum volume left atrial maximum volume chemotherapy cardiotoxity

Received: 09 April 2018

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	NIU Lin
	ZHAO Min
	ZHOU Fang
	LIU Jian
	BAO Lingyun

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2018/V48/I11/807

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