中西医联合治疗对闭合性骨折围手术期炎症的影响

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Abstract Objective: To explore the clinical curative effect of combined traditional Chinese medicine and western medicine in the treatment of infection in perioperative period of fracture. Methods: A total of 80 patients with closed fractures of extremities (upper and lower limbs) in Cixi Traditional Chinese Medicine Hospital from October 2014 to March 2016 were included. They were divided into the control group (clinical routine medicine) and the observation group (traditional Chinese medicine combined with clinical routine medicine). For each group of patients, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), white blood cell count (WBC), neutrophil (NEU) ratio, tumor necrosis factor-α (TNF-α), interleukin-1 (IL-1) and interleukin-6 (IL-6) were measured. Results: The CRP, ESR, WBC, NEU ratio, TNF-α, IL-1, IL-6 of the control group and observation group were the highest at 1 day after operation, then decreased at 5 days after operation, the difference was statistically significant (P<0.01). And the decrease of the observation group was more obvious. It was found in the late follow-up that there were 2 cases of infection in the control group and no infection patients in the observation group. Conclusion: The combined treatment of traditional Chinese medicine and Western medicine in perioperative period of fracture can decrease the inflammatory medium release, which may produce and added effect on the prevention of infection.

Key words： integrated traditional Chinese and western medicine therapy Wuwei Xiaodu Decoction Danggui Buxue Decoction bone fracture perioperative period infection

Received: 15 November 2017

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	YU Neng
	FANG Lue
	HUANG Xiaotao
	YAN Limin
	ZHANG Chi
	ZHOU Jiaen
	XIE Changfa.

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2018/V48/I10/764

[1] 王辉, 李世娟, 李春峰. 骨折患者术后医院感染相关因素调查分析[J]. 中华医院感染学杂志, 2008, 18(11): 1580-1580.
[2] 董晓宇, 周新社, 朱坤. 骨折内固定术后感染分期及治疗进展[J]. 创伤外科杂志, 2015, 17(3): 277-280.
[3] 国畅, 刘永华, 田丹生. 住院患者医院感染直接经济损失的统计与分析[J]. 中华医院感染学杂志, 2012, 22(8): 1651-1653.
[4] 周春莲, 陈惠清, 邓明卓. 某三级医院住院患者医院感染直接经济损失及控制策略研究[J]. 中华医院感染学杂志, 2014, 24(21): 5396-5398, 5431.
[5] 辛红, 庞丽娜, 刘浩. 感染和炎症与骨质再生的关系[J]. 解剖学研究, 2012, 34(4): 303-306.
[6] 马爱华, 刘盼, 郅红蕾, 等. 急诊发热患者C反应蛋白和降钙素原指标指导抗菌药物选择的临床研究[J]. 中华医院感染学杂志, 2017, 27(4): 774-776, 780.
[7] 向忠, 贺建军, 段晓明, 等. 骨科内置物术后早期联合白细胞、血沉、超敏C反应蛋白、降钙素原监测的临床意义[J]. 中国医学工程, 2017, 25(4): 14-17.
[8] 曹喜华, 王帅, 李海中, 等. 胸腰椎后路内固定术后早期手术部位感染患者的促炎因子和抗炎因子水平变化研究[J]. 中华医院感染学杂志, 2017, 27(1): 151-153.
[9] 卜文君, 郑莉丽, 钟奕, 等. 开放性骨折感染患者血清促炎及抗炎因子表达研究[J]. 中华医院感染学杂志, 2017, 27 (4): 846-848, 879.
[10] CARVALHO J K, MOORE D B, LUZ R A, et al. Prediction of sepsis-related outcomes in neonates through systematic genotyping of polymorphisms in genes for innate immunity and inflammation: a narrative review and critical perspective [J]. Sao Paulo Med J, 2013, 131(5): 338-350.
[11] 邓平征, 夏启水, 陶丽娟. 左氧氟沙星与五味消毒饮加减方对下肢骨折患者内固定术后早期抗感染的临床疗效评价[J]. 抗感染药学, 2017, 14(8): 1615-1617.
[12] 倪欢. 五味消毒饮加味联合抗生素治疗骨创伤术后创口感染疗效观察[J]. 实用中医药杂志, 2017, 33(4): 395-396.
[13] 黄凯, 张展, 刘亦杨, 等. 中西医结合治疗慢性创伤性股骨骨髓炎的临床疗效研究[J]. 中华中医药杂志, 2017, 32(1): 373-375.
[14] 康复笑, 徐其龙, 蔡安庆. 加味五味消毒饮辅助治疗细菌感染临床研究[J]. 现代养生(下半月版), 2017(3): 126-127.
[15] 邓海峰, 胡思斌, 郑继会, 等. 当归补血汤防治股骨粗隆间骨折术后隐性失血的疗效观察[J]. 中国中西医结合外科杂志, 2015, 21(6): 570-573.
[16] 熊晓莉. 五苓散与当归补血汤用于四肢骨折后肢体肿胀治疗的效果观察[J]. 临床合理用药杂志, 2017, 10(8): 61.
[17] 黄晓涛, 方略, 张弛, 等. 五味消毒饮合当归补血汤对III类骨折患者炎性相关指标的影响[J]. 浙江临床医学杂志, 2017, 19(1): 64-65.
[18] 谢长发, 黄晓涛, 张弛, 等. 中医药联合治疗开放性骨折及对围手术期炎性相关因子的影响[J]. 新中医, 2017, 49(11): 56-60.
[19] 周宗波, 朱华亮. 补中益气汤合五味消毒饮预防老年四肢骨折术后切口感染的临床研究[J]. 中医药导报, 2015, 21 (22): 56-58.