伴有抑郁症状的轻度认知功能障碍患者脑功能局部一致性

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Abstract Objective: To investigate the local consistency of brain function in patients with mild cognitive impairment with depressive symptoms. Methods: We scanned 16 patients with MCI with depressive symptoms and 18 MCI patients without depressive symptoms (nD-MCI) using the 3.0T MR scanner and obtained rs-fMRI data. Statistical analysis was used to assess the different regions of CReHo between the two groups. And the correlation between CReHo index and clinical scale was analyzed to evaluate the correlation between CReHo and pathophysiological indicators. Results: The CReHo value of the left Heschl and right thalamus areas in the D-MCI group was significantly higher than that in the non-depressive group, while the CReHo value of the left posterior central gyrus was reduced. In addition, our study also showed that the CReHo value of the left thalamus was positively correlated with the Hamilton Depression Scale (HAMD) score of D-MCI patients. Conclusion: These findings suggest that abnormal sensory motor network may be one of the main pathophysiological factors of D-MCI.

Key words： mild cognitive impairment depression functional magnetic resonance imaging regional consi-stency

Received: 13 January 2018

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	Articles by authors
	Chen Jiuzhun
	Zhou Shengfa
	Lin Feng
	He Chengbin
	Che Canwen.

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2018/V48/I10/754

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