正常糖耐量人群糖尿病家族史与血脂紊乱的相关性

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Abstract Objective: The normoglycemic first-degree relatives of patients with diabetes (FDR) are preferable for studies investigating metabolic abnormalities in the early stage of diabetes. The goal of the present study was to explore the association between the family history of diabetes and dyslipidemia. Methods: The present study population was selected from baseline survey of REACTION study in Wenzhou City. FDR was defined as having one or more first-degree relatives of patients with diabetes (parent, sibling, or offspring. Dyslipidemia was defined according to the Chinese guidelines on prevention and treatment of dyslipidemia in adults. The participants were divided into non-FDR and FDR groups based on their family history of diabetes. Comparisons of the prevalence of dyslipidemia and the levels of related metabolic indexes were conducted between these two groups. Results: Compared with non-FDR, FDR exhibited higher serum levels of TC, TG, and LDL-c, but lower levels of HDL-c (both P<0.05). The prevalence of dyslipidemia was greater in FDR (P<0.001). Multivariate analysis showed that TG, LDL-c, and HDL-c (both P<0.05) were associated with the first-degree family history of diabetes independently. Logistic regression analysis revealed the independent association between the first-degree family history of diabetes and the present of dyslipidemia (P<0.001). Conclusion: FDR are prone to dyslipidemia even with normal glucose tolerance and weight. First-degree family history of diabetes is an independent risk factor of the present of dyslipidemia.

Key words： first-degree relatives of patients with diabetes dyslipidemia normal glucose tolerance

Received: 28 June 2018

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	Articles by authors
	HU Xiang
	GU Xuejiang
	YANG Lijuan
	LIN Yi
	YU Weihui
	SI Qiya

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2018/V48/I10/723

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