自体荧光喉镜对早期喉癌及癌前病变的诊断价值

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Abstract Objective: To study the diagnostic value of autologous fluorescence laryngoscope for early laryngeal carcinoma and precancerous lesions. Methods: A total of 122 patients, who were suspected with early laryngeal cancer or precancerous lesion and treated at the First Affiliated Hospital of Wenzhou Medical University from July 2014 to July 2016, were examined by both white light and autofluorescence laryngoscopy. The sensitivity and specificity of the two methods were compared based on histopathological diagnosis. Results: The histopathological diagnosis of high and low risk lesions were 95 and 27 respectively. There were 82 and 66 high-risk lesions detected by autofluorescence laryngoscope and ordinary white laryngoscope respectively. The sensitivity of autologous fluorescence laryngoscope and ordinary white laryngoscope was 86.3% and 69.5% (P=0.005) respectively, and the specificity was 51.9% and 63.0% respectively (P=0.409). Twenty cases of early laryngeal cancer or precancerous lesions which had been missed by ordinary white light laryngoscope were detected by autologous fluorescence laryngoscope. Precancerous lesions or precancerous lesions appeared to be surrounded by green fluorescence under autologous fluorescence laryngoscope. Conclusion: Autologous fluorescence laryngoscope is helpful for early diagnosis of laryngeal carcinoma and provides guidance for biopsy and surgical resection of laryngeal carcinoma.

Key words： laryngeal neoplasms autofluorescence laryngoscopy white-light laryngoscopy diagnosis

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	Articles by authors
	WU Xianmin
	PENG Jianhua
	LI He
	CHEN Jun
	CHEN Xiaoyun

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2018/V48/I8/587

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