人巨细胞病毒感染与川崎病的相关性

Abstract
Figure/Table
References (0)
Related Citation (15)

Download: PDF (1267 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective: To investigate the human cytomegalovirus (HCMV) antibody levels in peripheral blood in children with Kawasaki disease (KD) and its correlation with the clinical characteristics of KD. Methods: Two hundred and thirty three children with KD, 113 healthy children and 143 children with fever were collected for retrospective analysis from the Second Affliated Hospital & Yuying Children’s Hospital of Wenzhou Medical University from March 2005 to December 2013. Then 58 KD children, 40 healthy children and 40 children with fever were collected for verification analysis. The relationship between clinical characteristics, laboratory indexes and HCMV infection in KD children was analyzed. Results: Retrospective analysis showed that the HCMV IgM positive rate of KD children was lower than fever children (P<0.05), but had no statistical difference from healthy children (P>0.05). The HCMV IgM positive rate of healthy children was also lower than fever children (P<0.05). And there were no statistical difference in IgG positive rate, IgM and IgG antibody titer level among three groups. The verification analysis found that IgM, IgG positive rate and IgM antibody titer level were not statistically different among three groups (P>0.05). But the IgG antibody titer level of KD children was higher than healthy children and fever children (P<0.05). The realation between HCMV infection and clinical features of KD children showed that the incidence of coronary artery injury in HCMV IgM positive children with KD was obviously higher than that of HCMV IgM negative children (P<0.05). There was no difference in the incidence of coronary artery injury in children with HCMV IgG positive and HCMV IgG negative. Conclusion: There is no correlation between HCMV infection and the occurrence of KD. However, HCMV infection may be associated with the progression of coronary artery lesion in KD children.

Key words： Kawasaki disease cytomegalovirus coronary artery lesions immunoglobulin M immunoglobulin G

	Service
	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	YU Lili
	LU Jiacheng
	XUE Xiangyang
	QIU Huixian
	WU Rongzhou
	CHU Maoping

URL:

https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2018/V48/I8/557

[1] KIM G B, PARK S, EUN L Y, et al. Epidemiology and clinical features of Kawasaki disease in South Korea, 2012-2014[J]. Pediatr Infect Dis J, 2017, 36(5): 482-485.
[2] MAKINO N, NAKAMURA Y, YASHIRO M, et al. Descriptive epidemiology of Kawasaki disease in Japan, 2011-2012: from the results of the 22nd nationwide survey[J]. J Epidemiol, 2015, 25(3): 239-245.
[3] NEWBURGER J W, TAKAHASHI M, BURNS J C. Kawasaki disease[J]. J Am Coll Cardiol, 2016, 67(14): 1738-1749.
[4] REINHARDT B, SCHAARSCHMIDT P, BOSSERT A, et al.
Upregulation of functionally active vascular endothelial
growth factor by human cytomegalovirus[J]. J Gen Virol, 2005, 86(Pt 1): 23-30.
[5] USTA G B, CENGIZ N, YILDIRIM S V, et al. Cytomegalovirus infection in a patient with atypical Kawasaki disease [J]. Rheumatol Int, 2008, 28(4): 387-389.
[6] CATALANO-PONS C, QUARTIER P, LERUEZ-VILLE M, et al. Primary cytomegalovirus infection, atypical Kawasaki disease, and coronary aneurysms in 2 infants[J]. Clin Infect Dis, 2005, 41(5): e53-56.
[7] 《中华儿科杂志》编辑委员会, 中华医学会儿科学分会心血管学组, 中华医学会儿科学分会免疫学组. 川崎病专题讨论会纪要[J]. 中华儿科杂志, 2007, 45(11): 826-830.
[8] POPOVIĆ M, SMILJANIĆ K, DOBUTOVIĆ B, et al. Human cytomegalovirus infection and atherothrombosis[J]. J Thromb Thrombolysis, 2012, 33(2): 160-172.
[9] NEWBURGER J W, TAKAHASHI M, GERBER M A, et al.
Diagnosis, treatment, and long-term management of Kawasaki disease: a statement for health professionals from the Committee on Rheumatic Fever, Endocarditis and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart Association[J]. Circulation, 2004, 110(17): 2747-2771.
[10] HOLMAN R C, BELAY E D, CHRISTENSEN K Y, et al. Hospitalizations for Kawasaki syndrome among children in the United States, 1997-2007[J]. Pediatr Infect Dis J, 2010, 29(6): 483-488.
[11] ROWLEY A H. Kawasaki disease: novel insights into etiology and genetic susceptibility[J]. Annu Rev Med, 2011, 62: 69-77.
[12] YOSHIOKA T, MATSUTANI T, TOYOSAKI-MAEDA T, et al. Relation of streptococcal pyrogenic exotoxin C as a causative superantigen for Kawasaki disease[J]. Pediatr Res, 2003, 53(3): 403-410.
[13] ROWLEY A H, SHULMAN S T, GARCIA F L, et al. Cloning the arterial IgA antibody response during acute Kawasaki disease[J]. J Immunol, 2005, 175(12): 8386-8391.
[14] CHANG L Y, LU C Y, SHAO P L, et al. Viral infections associated with Kawasaki disease[J]. J Formos Med Assoc, 2014, 113(3): 148-154.
[15] TURNIER J L, ANDERSON M S, HEIZER H R, et al. Concurrent respiratory viruses and Kawasaki disease[J]. Pediatrics, 2015, 136(3): e609-614.
[16] 郑岩. 117例川崎病与EB病毒感染[C]. 郑州: 中华医学会全国儿科学术大会, 2012.
[17] REEVES M, SINCLAIR J. Aspects of human cytomegalovirus latency and reactivation[J]. Curr Top Microbiol Immunol, 2008, 325: 297-313.
[18] VANEGAS F, MONTALVO R D, ALVAREZ O A, et al. Massive upper gastrointestinal hemorrhage due to cytomegalovirus infection in two patients with acquired immunodeficiency syndrome[J]. South Med J, 2000, 93(2): 235-238.
[19] LOZINGUEZ O, ARNAUD E, VELUT J G, et al. Cytomegalovirus and arterial disease. Current aspects[J]. Arch Mal Coeur Vaiss, 1999, 92(9): 1205-1212.
[20] MARCHETTE N J, MELISH M E, HICKS R, et al. Epstein-Barr virus and other herpesvirus infections in Kawasaki syndrome[J]. J Infect Dis, 1990, 161(4): 680-684.
[21] LEE S J, LEE K Y, HAN J W, et al. Epstein-Barr virus antibodies in Kawasaki disease[J]. Yonsei Med J, 2006, 47(4): 475-479.
[22] FUKAZAWA R, IKEGAM E, WATANABE M, et al. Coronary artery aneurysm induced by Kawasaki disease in children show features typical senescence[J]. Circ J, 2007, 71 (5): 709-715.
[23] XIAO M, MEN L N, XU M G, et al. Berberine protects endothelial progenitor cell from damage of TNF-α via the PI3K/AKT/eNOS signaling pathway[J]. Eur J Pharmacol, 2014, 743: 11-16.
[24] SHEN Y H, ZHANG L, UTAMA B, et al. Human cytomegalovirus inhibits Akt-mediated eNOS activation through upregulating PTEN (phosphatase and tensin homolog deleted on chromosome 10)[J]. Cardiovasc Res, 2006, 69(2): 502-511.
[25] DENGLER T J, RAFTERY M J, WERLE M, et al. Cytomegalovirus infection of vascular cells induces expression of pro-inflammatory adhesion molecules by paracrine action of secreted interleukin-1beta[J]. Transplantation, 2000, 69 (6): 1160-1168.
[26] TAKAHASHI K, OHARASEKI T, NAOE S. Pathological study of postcoronary arteritis in adolescents and young adults: with reference to the relationship between sequelae of Kawasaki disease and atherosclerosis[J]. Pediatr Cardiol, 2001, 22(2): 138-142.
[27] 邓正铭. 病毒感染与川崎病的相关性探讨[J]. 临床肺科杂志, 2015(9): 1652-1654, 1655.

[1]	. [J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2022, 52(6): 498-501.