腹部脂肪分布与结直肠息肉的相关性

Abstract
Figure/Table
References (0)
Related Citation (3)

Download: PDF (1196 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective: To investigate the correlation between distribution of adipose tissue and the risk of colorectal polyps and to provide clinical evidence for the etiology of colorectal polyps and building efficient prophylactic measures. Methods: 330 patients with colorectal polyps (Polyps group) and 546 controls without colorectal polyps (non-polyp group) were retrospectively analyzed. All subjects underwent computerized tomography (CT). With the MATLAB2013 analysis software and obesity was evaluated by visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), total adipose tissue (TAT), VAT/TAT, body mass index (BMI). The obesity between different gender, different pathological type, different number of polyp, different size of polyp was compared. Results: There were significant differences in the VAT, VAT/TAT and BMI between polyps group and non-polyp group. There were no significant differences in the levels of VAT, SAT, VAT/TAT between colorectal polyps with different pathological type, size and number (P>0.05). Multivariate analysis showed a higher VAT (OR=2.544, 95%CI: 1.551-4.173) and VAT/TAT (OR=2.103, 95%CI: 1.262-3.516) were independently associated with the risk of colorectal polyps in male (P<0.05), while no significant difference in female (P>0.05). Conclusion: VAT and SAT are not correlated with the pathological type, size and number of colorectal polyps. VAT and SAT are not correlated with colorectal polyps in female. Visceral adiposity measured by VAT, VAT/TAT is associated with an increased risk of colorectal polyps in male, while the SAT is not associated with the risk of colorectal polyps in male.

Key words： colorectal polyps adipose tissue visceral adipose tissue

Received: 30 June 2017

	Service
	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	YE Huajun
	XU Hanyan
	JIANG Xuepei
	HE Xixi
	HUANG Zhiming.

URL:

https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2018/V48/I7/490

[1] COMSTOCK S S, HORTOS K, KOVAN B, et al. Adipokines and obesity are associated with colorectal polyps in adult males: a cross-sectional study[J]. PLoS One, 2014, 9 (1): e85939.
[2] LEE J Y, KWAK S M, MYUNG S K, et al. Obesity and colorectal adenomatous polyps: a cross-sectional study in Korean adults[J]. Obesity (Silver Spring), 2014, 22(2): 518-525.
[3] KIMURA Y, MATSUMOTO H, OOSAWA M, et al. Relationship between visceral fat and development of colorectal neoplasms using computed tomographic colonography and adipocytokine levels[J]. Nihon Shokakibyo Gakkai Zasshi, 2014, 111(11): 2121-2130.
[4] MATHIEU P, POIRIER P, PIBAROT P, et al. Visceral obesity: the link among inflammation, hypertension, and cardiovascular disease[J]. Hypertension, 2009, 53(4): 577-584.
[5] SAMARAS K, BOTELHO N K, CHISHOLM D J, et al. Subcutaneous and visceral adipose tissue gene expression of serum adipokines that predict type 2 diabetes[J]. Obesity (Silver Spring), 2010, 18(5): 884-889.
[6] SEKINE K, NAGATA N, SAKAMOTO K, et al. Abdominal visceral fat accumulation measured by computed tomography associated with an increased risk of gallstone disease [J]. J Gastroenterol Hepatol, 2015, 30(8): 1325-1331.
[7] GOODPASTER B H. Measuring body fat distribution and content in humans[J]. Curr Opin Clin Nutr Metab Care, 2002, 5(5): 481-487.
[8] 李景南, 赵莉, 郑威扬, 等. 结肠癌近20年临床特点的变迁分析[J]. 中华内科杂志, 2010, 49(3): 226-229.
[9] 苗大壮, 刘正, 王锡山. 代谢异常对结直肠癌发病的影响 [J]. 中华消化外科杂志, 2014, 13(12): 995-998.
[10] 房静远. 预防是控制结直肠癌的关键[J]. 中华消化杂志, 2015, 35(3): 145-147.
[11] GUARINOS C, SANCHEZ-FORTUN C, RODRIGUEZ-SOLER M, et al. Serrated polyposis syndrome: molecular, pathological and clinical aspects[J]. World J Gastroenterol, 2012, 18(20): 2452-2461.
[12] KANG H W, KIM D, KIM H J, et al. Visceral obesity and insulin resistance as risk factors for colorectal adenoma: a cross-sectional, case-control study[J]. Am J Gastroenterol, 2010, 105(1): 178-187.
[13] LYON C J, LAW R E, HSUEH W A. Minireview: adiposity, inflammation, and atherogenesis[J]. Endocrinology, 2003, 144(6): 2195-2200.
[14] JUGE-AUBRY C E, HENRICHOT E, MEIER C A. Adipose tissue: a regulator of inflammation[J]. Best Pract Res Clin Endocrinol Metab, 2005, 19(4): 547-566.
[15] BATRA A, PIETSCH J, FEDKE I, et al. Leptin-dependent toll-like receptor expression and responsiveness in preadipocytes and adipocytes[J]. Am J Pathol, 2007, 170(6): 1931-1941.
[16] NEUMEIER M, WEIGERT J, SCHAFFLER A, et al. Different effects of adiponectin isoforms in human monocytic cells[J]. J Leukoc Biol, 2006, 79(4): 803-808.
[17] LUMENG C N, DEYOUNG S M, BODZIN J L, et al. Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity[J]. Diabetes, 2007, 56(1): 16-23.
[18] MANTOVANI A, SICA A, SOZZANI S, et al. The chemokine system in diverse forms of macrophage activation and polarization[J]. Trends Immunol, 2004, 25(12): 677-686.
[19] GRAHN S W, VARMA M G. Factors that increase risk of colon polyps[J]. Clin Colon Rectal Surg, 2008, 21(4): 247-255.
[20] LEUNG W K, HO K Y, KIM W H, et al. Colorectal neoplasia in Asia: a multicenter colonoscopy survey in symptomatic patients[J]. Gastrointest Endosc, 2006, 64(5): 751-759.
[21] MACOTELA Y, BOUCHER J, TRAN T T, et al. Sex and depot differences in adipocyte insulin sensitivity and glucose metabolism[J]. Diabetes, 2009, 58(4): 803-812.
[22] ROSSOUW J E, ANDERSON G L, PRENTICE R L, et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women’s Health Initiative randomized controlled trial[J]. JAMA, 2002, 288(3): 321-333.
[23] DONOHOE C L, DOYLE S L, REYNOLDS J V. Visceral
adiposity, insulin resistance and cancer risk[J]. Diabetol Metab Syndr, 2011, 3: 12.
[24] PARK J, EUHUS D M, SCHERER P E. Paracrine and endocrine effects of adipose tissue on cancer development and progression[J]. Endocr Rev, 2011, 32(4): 550-570.
[25] ZAUBER A G, WINAWER S J, O’BRIEN M J, et al. Colonoscopic polypectomy and long-term prevention of colorectal-cancer deaths[J]. N Engl J Med, 2012, 366(8): 687-696.