显微镜下多血管炎肺损害20例临床分析

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Abstract Objective: To analyze the clinical characters of pulmonary involvement in the patients with microscopic polyangiitis. Methods: Twenty cases of MPA with pulmonary involvement were analyzed retrospectively, including clinical manifestation, laboratory test results, chest high-resolution computed tomography, pulmonary function test and pathology. Results: The common symptoms were cough (85%), dyspnea (30%), expectoration (25%) and haemoptysis (20%). Erythrocyte sedimentation rate was elevated in 95% of MPA patients. C-reactive protein was elevated in 55%. The prevalence of positive MPO-ANCA antibodies in MPA patients was 90%, while PR3-ANCA was 5%. Chest HRCT manifestations consisted of ground-glass opacity, interstitial fibrosis, patchy infiltration, pleural effusion and bronchiectasis. Conclusions: The pulmonary is frequently involved in MPA. Pulmonary involvement is the initial manifestation. The chest radiographic and clinical manifestations are nonspecific. Serum ANCA and histopathologic biopsy can help to understand and diagnose MPA with pulmonary involvement early.

Key words： microscopic polyangiitis pulmonary involvement anti-neutrophil cytoplasmic antibody high-resolution computed tomography

Received: 26 March 2013

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	JIN Xiaosheng1
	WU Lifeng1
	QIAN Xiaoying1
	WANG Wantie2

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2014/V44/I3/219