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| Clinical and pathological analyse for renal injury of IgA nephropathy with thrombotic microangiopathy secondary to malignant hypertension |
| HUANG Huiya1，LV Yinqiu2，ZHAO Runying3，CHEN B02，XU Feifei2，sU Zhen2． |
| i．Department ofIntensive Care Unit．the First Affiliated Hospital of Wenzhou Medical College．Wenzhou，325000；2．Department ofNephrology,the First Affiliated Hospital of Wenzhoa Medical College，Wenzhou，325000；3．Department of Nephrology，Integrated Chinese and Western Medicine Hospital of Wenzhou，Wenzhou，325000 |
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| Cite this article: |
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HUANG Huiya,LV Yinqiu,ZHAO Runying, et al. Clinical and pathological analyse for renal injury of IgA nephropathy with thrombotic microangiopathy secondary to malignant hypertension[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2013, 43(3): 187-190.
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Abstract 0bjective：To evaluate the characteristic of clinical and pathological of IgA nephropathy with thrombotic microangiopathy(TMA)secondary to malignant hypertension patients．Methods：From Feb．2004 to Dec．20 1 1，a case control retrospective study was carried out in 5 cases of IgAN with TMA which secondary to malignant hypertension and 6 cases of TMA secondary to malignant hypertension as contr01．Results：Clinical manifestation of two groups showed that both groups had malignant hypertension，hematuria，proteinuria and renal injury．The IgAN group had significantly higher proteinuria and hematuria(P<0．05，VS un-IgAN group)；kidney pathology of 1 l cases showed that the IgA group possessed severer glomerular pathological changes and the degree of pathological changes of glomerular artery was inferior than un—IgAN group．Conclusion：IgA nephropathy with TMA secondary to malignant hypertension is different from that without IgAN in clinical andpathological manifestation．When it is difficult to diagnosis，renal biopsy is an important method to identify these two diseases
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