2001-2011年浙江省急性心肌梗死患者ACEI/ARB应用情况及其影响因素

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Abstract Objective: To evaluate patterns of angiotensin-converting enzyme inhibitors/angiotensin receptor blockers (ACEI/ARB) therapy in patients with acute myocardial infarction (AMI) in Zhejiang Province from 2001 to 2011, and to identify factors affecting the use of ACEI/ARB. Methods: Clinical information of AMI patients from 8 hospitals in Zhejiang Province were collected in 2001, 2006 and 2011, and patterns of ACEI/ARB therapy by year were analyzed. Binary logistic regression analysis was used to identify factors related to the use of ACEI/ARB. Results: A total of 604 patients were included, of whom 590 were eligible for Class I indication by Chinese guidelines and 14 were eligible for Class IIa indication. From 2001 to 2011, the use of ACEI/ARB in patients with Class I indication and Class IIa indication were 73.26%, 72.16%, 60.65% (P=0.005) and 0, 50.00%, 45.45% (P=0.513) respectively. In the three specific years to be studied, the use rate of ACEIs in patients with Class I indication was noticeably higher than that of ARBs. Binary logistic regression analysis showed that patients with Class I indication complicated with hypertension (OR=3.8, 95%CI=2.5-5.9), eGFR unmeasure (OR=15.7, 95%CI=6.9-35.6) were more likely to be treated with ACEI/ARB, and patients with LVEF value unmeasured (OR=0.3, 95%CI=0.2-0.5), eGFR< 60 mL/(min·1.73 m2) (OR=0.3, 95%CI=0.2-0.5) were less likely to be treated with ACEI/ARB. Conclusion: There’s little improvement in the use rate of ACEI/ARB therapy during hospitalization in AMI patients with Class I indication in Zhejiang Province from 2001 to 2011. Further efforts should be devoted to enhancing the compliance of therapy with current practice guidelines to improve the medical care.

Key words： acute myocardial infarction angiotensin-converting enzyme inhibitors angiotensin receptor blockers

Received: 22 January 2018

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	GE Weili
	MI Yafei
	JIANG Jianjun
	XUE Yingsheng
	WANG Bin
	LI Tao.

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2018/V48/I6/424

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