富血小板纤维蛋白联合自体骨髓浓缩物修复骨缺损的早期疗效

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Abstract Objective: To assess the initial effects of platelet-rich fibrin (PRF) in conjunction with bone marrow aspirate concentrate (BMAC) on reconstruction of bone defect. Methods: Four bone defects of 5-mm in diameter were performed in the calvaria of 6 rabbits. These defects were randomly filled with blood clot (group A), autogenous bone (group B), PRF and BMAC (group C). Meanwhile, PRF was collected for histological observation. Animals were sacrificed 6 weeks later, and bone samples were harvested for histological observation and statistical analysis. Results: PRF was milk white fibrin glue with elasticity and toughness. The loose and porous three dimensional network structure and white blood cells at the bottom of PRF could be seen in the histological sections. The percentage of new bone formed in each group was 7.64%±1.02% (group A), 12.94%±0.81% (group B), 37.19%±1.26% (group C), respectively. Group C showed a statistically greater amount of new bone formation compared with group A and group B (P<0.05). Conclusion: PRF mixed with BMAC couldaccelerate the regeneration of new bone to repair the rabbit calvarial defect.

Key words： platelet-rich fibrin bone marrow aspirate concentrate bone regeneration

Received: 07 August 2017

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	Articles by authors
	YANG Ying
	LIU Guo
	LIU Chuantong
	JIN Qiong
	ZHU Fei.

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2018/V48/I5/375

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