PI3Kp85α在甲状腺乳头状癌中的表达及意义

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Abstract Objective: To explore the expression and significance of phosphatidylinositol 3-kinase regulatory subunit alpha (PI3Kp85α) in papillary thyroid carcinoma (PTC). Methods: PI3Kp85α expressions were detected in PTC tissues (n=116) and thyroid papillary hyperplasia (PTH) tissues (n=90) by immunohistochemistry, Western blot, and enzyme-linked immunosorbent assay. The relationships between PI3Kp85α expressions and clinical pathological features in PTC were analyzed. Diagnostic values of PI3Kp85α in PTC were evaluated by receiver operating characteristic (ROC) curve. Results: PI3Kp85α expression levels in PTC tissues were statistically higher than those in PTH tissues (P<0.05). PI3Kp85α expression was associated with lymph node metastasis (P<0.05). The diagnostic sensitivity and specificity of PI3Kp85α were 92.2% and 91.1%, respectively, with a cut-off value of 2.100 and an area under curve of 0.966. Conclusion: PI3Kp85α may be related to the tumorigenesis and progression of PTC.

Key words： thyroid neoplasms phosphatidylinositol 3-kinase vegulatory subunit alpha pathology, clinical diagnosis

Received: 07 November 2017

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	GONG Xiaohua
	ZHOU Qi
	WU Wenjun
	WANG Fang
	CHEN Xiaojun

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2018/V48/I5/371

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