活化血浆凝固时间对免疫性血小板减少症患者出血的风险评估

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Abstract Objective: To investigate the value of activated plasma clotting time (APCT) for assessing the bleeding diathesis of immune thrombocytopenia. Methods: There were one hundred and twenty-eight patients of diopathic immune thrombocytopenia. Taking the patient抯 venous blood, the patient抯 blood platelet count and activated plasma clotting time were determined. The patients were devided into two groups by platelet count, one group抯 platelet count was lower than 30×109/L, and the other group抯 platelet count was 30×109/L～79×109/L.Acorrding to the test, we could get APCT. By analyzing APCT and Khellaf bleeding score, we could receive that APCT and Khellaf bleeding score results had linear correlation. Results: We set APCT critical point was high than ninety seconds. The sensibility to assess the ITP patient抯 bleeding was 100%, the specificity is 91.3% and the false positive rate 8.69%. In the group抯 platelet count was lower than <30×109/L, we could receive that APCT and Khellaf bleeding score results had linear positive correlation, P=0.013, r=0.968. In the group抯 platelet count was about 30×109/L～79×109/L, we could receive that APCT and Khellaf bleeding score results had correlation,P=0.01, r=0.764. Conclusion: APCT has a good sensibility and specificity. It is a good predictive index to assessing the bleeding of ITP.q

Key words： immune thrombocytopenia activated plasma clotting time blood platelet count Khellaf bleeding score system

Received: 26 August 2013

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	HE Muqing1
	HE Muqun2
	LIN Xiaoji1.

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2014/V44/I3/197

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