磁共振体素内不相干运动成像评价糖尿病肾功能高滤过期的价值

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Abstract Objective: To investigate whether the intravoxel incoherent motion diffusion weighted imaging (IVIM-DWI) was helpful in assessing renal function changes in early-stage diabetic patients with hyperfiltration. Methods: A total of 12 diabetic patients with eGFR≥120 mL•min-1•1.73 m-2 and 12 healthy controls were included in the study. IVIM-DWI of bilateral kidneys was acquired using 11 b values on a 3.0 T MR scanner. The diffusion coefficient of apparent diffusion coefficient (ADC), pure molecular diffusion (D), perfusion-related pseudo-diffusion coefficient (DP) and perfusion fraction (PF) of the renal cortex and medullawere calculated from IVIM-DWI maps of the two groups. Two radiologists independently analyzed all imaging data. Intra-class correlation coefficients (ICCs) and group comparisons by two-sided t-test were made between the two groups. Relationship between IVIM-DWI parameters and eGFR was examined by Spearman correlation test.Results: Inter-observer agreement was “good” (ICC=0.764-0.874) for all parameters. Mean renal cortex and medulla ADC, D and PF value of diabetic patients were significantly higher than healthy controls (P<0.05). There was a significant linear correlation between renal cortex D value and eGFR level (r=0.581, P<0.05). Conclusion: It is indicated that ADC, D and PF value could detect the renal changes of water molecular diffusion and microcirculation perfusion in diabetic kidneys which may emerge as glomerular hyperfiltration that occurs in early-stage diabetic kidneys. However, it is still a challenge for DP value to reflect microcirculation perfusion changes.

Key words： kidney magnetic resonance imaging intravoxel incoherent motion prediabetic state glomerular filtration rate

Received: 18 January 2018

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	ZHOU Yongjin
	YE Xinjian
	GONG Enhui
	HUANG Xiaoyan
	CUI Shihan
	SONG Jiawen
	LIU Kun
	YAN Zhihan

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2018/V48/I5/366

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