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| Clinical significance of blood coagulation function and lupus anticoagulant detection in patients withankylosing spondylitis |
| PAN Xiaohao1, CHEN Liyang2, ZHOU Jian1 |
| 1.Department of Clinical Laboratory,Wenzhou Hospital of Integrated Chinese and Western Medicine, Wenzhou 325000, China; 2.Department of Clinical Laboratory, the Second People’s Hospital of Longwan District, Wenzhou 325000, China |
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| Cite this article: |
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PAN Xiaohao,CHEN Liyang,ZHOU Jian. Clinical significance of blood coagulation function and lupus anticoagulant detection in patients withankylosing spondylitis[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2024, 54(10): 839-842.
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Abstract Objective: To investigate the clinical significance of coagulation function and lupus anticoagulant(LAC) detection in patients with ankylosing spondylitis (AS). Methods: A total of 60 patients who were diagnosed with AS in Wenzhou Hospital of Integrated Chinese and Western Medicine from July 2020 to June 2023 were selected as the experimental group, and 60 healthy people during the same period were selected as the control group. The levels of routine coagulation function [prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB), thrombin time (TT), D-dimer (D-D)] and LAC were detected in the two groups. Mann-Whitney U test was used to compare the differences in the above indicators, and ROC curve was drawn to analyze the auxiliary diagnostic efficiency of each indicator. Results: There was significant difference in the levels of PT, APTT, FIB, DD and LAC between AS patients and healthy control group (P<0.05). The area under ROC curve of LAC, FIB and D-D was 0.97, 0.93 and 0.84, respectively. The Youden index was 0.90, 0.78 and 0.58, respectively.The sensitivity was 96.70%, 85.00% and 71.70%, respectively. Conclusion: Patients with AS have the risk of thrombosis, and the detection of coagulation function and LAC is of certain value in the auxiliary diagnosis.
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Received: 28 December 2023
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. [J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2024, 54(6): 498-500. |
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