不同饮酒量对脂肪肝患者肝功能和糖代谢的影响

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摘要目的：比较不同饮酒量对脂肪肝患者肝功能和糖代谢的影响。方法：选取体检中心、门诊及病房确诊为脂肪肝的患者，根据饮酒量分为不饮酒组、适量饮酒组、过量饮酒组，比较患者一般情况、肝功能指标和糖代谢指标。结果：共收集207例脂肪肝患者，其中适量饮酒组62例，不饮酒组75例，过量饮酒组70例。适量饮酒组收缩压显著低于另外2组，舒张压显著低于过量饮酒组，体质量指数（BMI）及腰臀比（WHR）低于另外2组（P＜0.05）。适量饮酒组丙氨酸转氨酶（ALT）、总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白（LDL-C）低于另外2组（P＜0.05），高密度脂蛋白（HDL-C）高于另外2组（P＜0.05）。适量饮酒组糖化血红蛋白（HbA1c）、HOMA-IR低于另外2组（P＜0.05），胰岛素作用指数（IAI）高于另外2组（P＜0.05）。结论：脂肪肝患者适量饮酒可以从血压、BMI、WHR、肝功能、心血管、胰岛素抵抗等方面获益。

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关键词 ：脂肪肝, 适量饮酒, 胰岛素抵抗, 多普勒超声

Abstract：Objective: To compare the effects of different alcohol consumptions on liver function and glucose metabolism in fatty liver patients. Methods: The patients diagnosed with fatty liver from physical examination center, outpatient services and inpatient department, were divided into 3 groups: non-drinking group, modest-drinking group and heavy-drinking group according to the amount of alcohol consuming. Then, the details of patients’ information include general physical condition, liver function and glucometabolic index were compared. Results: A total of 75 non-drinking patients, 62 modest-drinking patients, 70 heavy-drinking patients were collected. The modest-drinking group had a significantly lower level of systolic blood pressure (SBP) compared with other two groups and a significantly lower level diastolic blood pressure (DBP) compared with heavy-drinking group (P<0.05). In the comparison of body mass index (BMI) and waist-hip ratio (WHR), the modest-drinking group was the smallest (P<0.05). The modest-drinking group had significantly lower alanine transaminase (ALT), total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and significantly higher high-density lipoprotein cholesterol (HDL-C) than those of other two groups (P<0.05). The modest-drinking group had significantly lower hemoglobin A1c (HbA1c) and homeostasis model assessment-insulin resistance (HOMA-IR), significantly higher insulin action index (IAI) than other two groups (P<0.05). Conclusion: Compared with the patients of non-drinking group and heavy-drinking group, the patients in modest-drinking group could

benefit from blood pressure, BMI, WHR, liver function, cardiovascular system, insulin resistance and so on.

Key words： fatty liver modest alcohol drinking insulin resistance ultrasonography

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通讯作者: 吴金明，主任医师，Email：327357738@qq.com

作者简介: 陆东东（1990-），男，浙江宁波人，硕士生

链接本文:

https://xb.wmu.edu.cn/CN/ 或 https://xb.wmu.edu.cn/CN/Y2018/V48/I1/38

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