DRD4基因多态性对注意缺陷多动障碍儿童静息态脑功能磁共振的影响

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摘要目的：探讨多巴胺D4受体（DRD4）基因多态性对注意缺陷多动障碍（ADHD）儿童静息态脑功能磁共振（rs-fMRI）的影响。方法：对30例DRD4 4R/4R基因型ADHD儿童（DRD4 4R/4R组）和19例DRD4 2R基因型（DRD4 2R组）ADHD儿童均进行rs-fMRI扫描，采用局部一致性（ReHo）及基于种子点的功能连接作为测量指标，比较2组ADHD不同基因型之间rs-fMRI差异。结果：DRD4 4R/4R组较DRD4 2R组ADHD儿童ReHo值升高的脑区有双侧小脑后叶、舌回，右侧颞枕叶；ReHo值降低的脑区有左侧角回。与左侧角回功能连接增强的脑区有右侧额叶及两侧小脑；功能连接减弱的脑区有两侧枕叶及左侧额叶。结论：2组DRD4不同基因型的ADHD儿童之间多个脑区ReHo值和脑功能连接强度存在显著差异，为解释DRD4基因多样性对ADHD儿童rs-fMRI影响提供了研究基础。

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	钱安丹
	王美豪
	王欣
	刘会茹
	李建策
	杨闯

关键词 ：注意缺陷多动障碍, 多巴胺D4受体, 静息态脑功能磁共振

Abstract：Objective: To investigate the influence of dopamine D4 receptor (DRD4) gene polymorphism on brain resting-state functional magnetic resonance imaging (rs-fMRI) in children with attention deficit hyperactivity disorder (ADHD). Methods: rs-fMRI data was acquired in carriers of the DRD4 4-repeat/4-repeat (4R/4R) allele (DRD4 4R/4R group, n=30) and carriers of a DRD4 2-repeat (2R) allele (DRD4 2R group, n=19) in children with ADHD. The imaging characteristics of rs-fMRI between two ADHD genotypes were compared by using the methods of regional homogeneity (ReHo) and functional connectivity. Results: Compared with ADHD with a DRD4 2R allele, ADHD with DRD4 4R/4R allele showed increased ReHo in the bilateral cerebellum posterior lobe, the bilateral lingual gyrus and the right temporal occipital lobe. The decreased ReHo regions were the left angular gyrus. DRD4 4R/4R group showed functional connectivity increased to the left angular gyrus in the right frontal lobe and the bilateral cerebellum lobe. The functional connectivity decreased regions included the bilateral occipital lobe and the left frontal lobe. Conclusion: ReHo values and functional connectivity magnitude of many brain regions are significantly different between two groups of children with ADHD with different DRD4 genotypes. These findings could advance the understanding of the effects of DRD4 gene variation on children with ADHD in resting state.

Key words： attention deficit hyperactivity disorder dopamine D4 receptor resting-state functional magnetic resonance imaging

PACS:

基金资助:浙江省自然科学基金资助项目（LY14H180006）

通讯作者: 王美豪，教授，Email：wmh@wzhospital.cn

作者简介: 钱安丹（1990-），女，浙江温州人，住院医师，硕士

链接本文:

https://xb.wmu.edu.cn/CN/ 或 https://xb.wmu.edu.cn/CN/Y2018/V48/I1/26

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