新型纳米递送系统对肝癌靶向治疗作用的研究进展

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摘要肝癌是临床上比较常见的恶性肿瘤，随着对该病治疗方法不断改进，肝癌的分子靶向治疗具有较好的分子选择性，能高效并选择性地杀伤肿瘤细胞，减少对正常组织的损伤。药物靶向能够实现对肿瘤的高效低毒的治疗，而实现药物的靶向释放，则需要借助特殊的载体对药物进行递送。药物靶向递送系统能够在药物到达指定病变组织部位前阻止其释放，从而提高药物在指定组织部位的浓度和减小药物对其他正常组织部位的毒害。纳米递送系统作为一种新型、高效的药物递送系统越来越受到研究者的青睐。笔者通过对新型壳聚糖包覆阿霉素纳米递送系统的构建及其对肝癌抑制作用的研究，并对其他类型的纳米递送系统的主动肝靶向给药系统在药物/基因递送的最新进展进行综述。

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	杨寿璋
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关键词 ：肝癌, 靶向治疗, 纳米递送系统, 进展

收稿日期: 2017-03-13

基金资助:温州市科技计划项目（Y20160048）

通讯作者: 屠金夫，主任医师，Email：tujinfu@sina.com

作者简介: 杨寿璋（1989-），男，浙江温州人，住院医师，硕士

链接本文:

https://xb.wmu.edu.cn/CN/ 或 https://xb.wmu.edu.cn/CN/Y2017/V47/I12/927

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