ZHENG Xiuxia,HUANG Baoying,LAI Zijian, et al. Clinical observation of different doses of astragalus compound on patients with spinal cord injury with Qi deficiency and blood stasis[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2017, 47(11): 828-831,835.
Abstract：Objective: To observe the clinical effect of different doses of astragalus membranaceus on the patients with spinal cord injury due to Qi deficiency and blood stasis in Buyang Huanwu Decoction, and to provide the basis for clinical medication. Methods: Ninty spinal cord injury with Qi deficiency and blood stasis syndrome cases from July 2015 to December 2016 in orthopedics department of the Affiliated Ningde Hospital of Fujian Medical University, according to the order of the patients entered the trial, and to the random number table, randomly divided into 3 groups. Each group based on basic treatment, in a week after injury for traditional Chinese medicine (TCM) treatment, last one month, each group use basic prescription Buyang Huanwu Decoction. Group A with astragalus 30 grams, group B with 60 grams and group C with 120 grams, evaluated TCM syndrome score, the degree of spinal cord injury, activities of daily living (ADL) ability before and after traditional Chinese medicine treatment, judging TCM main symptoms and treatment efficacy after traditional Chinese medicine. Results: Compared with the main symptoms of Qi deficiency syndrome, group C was better than that of group A and B, the difference was statistically significant (P<0.05), group B was better than group A, the difference was statistically significant (P<0.05). Compared with the main symptoms of blood stasis syndrome, group C was better than that of group A and B, the difference was statistically significant (P<0.05), group B was better than group A, the difference was statistically significant (P<0.05). There was no significant difference between group A and B in the degree of SCI classification; the difference between group C and B was statistically significant, and also group C and A (P<0.05). Compared with ADL, there was no significant difference between group A and B, but the difference between group C and B was statistically significant, and also group C and A (P<0.05). Conclusion: Astragalus membranaceus 120 grams group is better than 60 grams group and 30 grams group in the treatment of SCI patients with Qi deficiency and blood stasis syndrome in different doses of Buyang Huanwu Decoction, which has a certain degree of dependence on measurement.
