LI Shanshan,NI Li,ZHU Lidan, et al. The establishment of biological reference intervals of prealbumin and cholinesterase in serum for children in Wenzhou[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2017, 47(11): 824-827.
Abstract：Objective: To establish the biological reference interval of serum prealbumin and cholinesterase for children (infant to school-age children) in Wenzhou. Methods: Retrospective study was adopted. The data of healthy infant (3 months to 12 years old) who visited the Second Affiliated Hospital of Wenzhou Medical University during April 2016 to March 2017 was collected. The qualified persons were divided into 6 groups according to gender and age, namely 3 months-3 years old (male, female infant group), -6 years old (male, female preschool group), 12 years old (male, female school-age group). By eliminating outliers within each group, 1 441 cases get qualified. Statistical methods was applied in comparing PA and CHE levels among the groups, if there was no statistical significance (P>0.05), the two age groups were merged, otherwise they won’t be merged. Results: The children’s serum PA reference intervals were 114.9-231.3, 126.4-237.4 and 136.7-273.5 mg/L for 3 months-3 years old, 4-6 years old, 7-12 years old. The difference of serum PA between male and female with the same age groups had no statistical significance (P>0.05). PA level was positively correlated with age (r=0.497, P<0.01). The children’s serum CHE reference intervals were 7 014-14 900, 7 079-14 246, 6 709-13 163 U/L for 3 months-6 years old, 7-12 years old (male), 7-12 years old (female). In addition to the school age group, the difference of serum CHE between male and female with the same age groups had no statistical significance (P>0.05). CHE level was not correlated with age (r=0.017, P>0.05). Conclusion: According to the research, reference intervals of PA and CHE are established for children at different age groups in the laboratory and reference in assessing children’s nutritional status and liver function are provided for clinicians.
