无视网膜病变糖尿病患者黄斑色素密度分析

摘要
图/表
参考文献
相关文章 (15)

全文: PDF (1344 KB) HTML (1 KB)
输出: BibTeX | EndNote (RIS)

摘要目的：研究糖尿病无视网膜病变患者黄斑色素密度（MPOD）与健康对照者间的差异，分析MPOD相关指标与生化指标的相关性。方法：筛选2型糖尿病无视网膜病变患者41例（糖尿病组）及同期健康对照者21例（对照组）。所有受检者均进行空腹血糖（GLU）、糖化血红蛋白（HbA1c）、胆固醇（CHOL）、甘油三酯（TG）、低密度脂蛋白（LDL）、高密度脂蛋白（HDL）、肌酐（CR）、尿素氮（BUN）、视黄醇结合蛋白（RBP）、同型半胱氨酸（HCY）的检验，并采用眼底光谱反射法测量糖尿病患者黄斑区平均光密度（Mean OD）、光密度最大值（Max OD）。结果：糖尿病组Mean OD水平[（0.15±0.03）du]较对照组[（0.16±0.02）du]降低，2组比较差异有统计学意义（P＜0.05）。Mean OD水平与HDL呈轻度正相关（r=0.28，P＜0.05）。结论：糖尿病无视网膜病变患者Mean OD较健康者降低；MPOD可能受血清中HDL水平的影响。

	服务
	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章
	徐丽娟
	俞瑞
	吕志刚

关键词 ：黄斑色素密度, 糖尿病, 视网膜疾病

Abstract：Objective: To compare macular pigment optical density (MPOD) between healthy Chinese people and type 2 diabetic patients without retinopathy using the one-wave length reflectometry and to evaluate the correlation of MPOD with serum lipid levels. Methods: Forty-one type 2 diabetes without retinopathy and 21 healthy controls were enrolled in this study. All subjects underwent blood tests which included glucose (GLU), glycated hemoglobin (HbA1c), cholesterol (CHOL), triglyceride (TG), low density lipoprotein (LDL), high density lipoprotein (HDL), creatinine (CR), blood urea nitrogen (BUN), retinol binding protein (RBP) and homocysteine (HCY). MPOD (including mean OD: mean macular pigment optical density and max OD: maximum macular pigment optical density) was measured with one-wavelength ophthalmoscope. Results: Mean OD of type 2 diabetes was lower than the normal controls [(0.15±0.03) du vs. (0.16±0.02) du, P<0.05]. Mean OD level was positively correlated with HDL (r=0.28, P<0.05). Conclusion: Mean OD in diabetic patients without retinopathy is lower than that of healthy controls, and MPOD may affected by HDL levels.

Key words： macular pigment optical density diabetes mellitus retinal diseases

收稿日期: 2017-03-23

基金资助:金华市科技局社会发展类重点项目（2015-3-011）。

通讯作者: 吕志刚，主任医师，硕士生导师，Email：jhyylzg@163.com

作者简介: 徐丽娟（1985-），女，浙江金华人，住院医师，硕士。

链接本文:

https://xb.wmu.edu.cn/CN/ 或 https://xb.wmu.edu.cn/CN/Y2017/V47/I11/820

[1] NISHIKAWA T, EDELSTEIN D, DU X L, et al. Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage[J]. Nature, 2000, 404 (6779): 787-790.
[2] GIACCO F, BROWNLEE M. Oxidative stress and diabetic complications[J]. Circ Res, 2010, 107(9): 1058-1070.
[3] MURIACH M, BOSCH-MORELL F, ALEXANDER G, et al. Lutein effect on retina and hippocampus of diabetic mice[J]. Free Radic Biol Med, 2006, 41(6): 979-984.
[4] SNODDERLY D M, BROWN P K, DELORI F C, et al. The macular pigment. I. Absorbance spectra, localization, and discrimination from other yellow pigments in primate reti-nas[J]. Invest Ophthalmol Vis Sci, 1984, 25(6): 660-673.
[5] 葛坚, 赵家良, 黎晓新. 眼科学[J]. 2版. 北京: 人民卫生出版社, 2010: 305-306.
[6] SCHWEITZER D, JENTSCH S, DAWCZYNSKI J, et al. Simple and objective method for routine detection of the macular pigment xanthophyll[J]. J Biomed Opt, 2010, 15(6): 61714.
[7] BONE R A, LANDRUM J T, TARSIS S L. Preliminary identification of the human macular pigment[J]. Vision Res, 1985, 25(11): 1531-1535.
[8] LANDRUM J T, BONE R A, KILBURN M D. The macular pigment: a possible role in protection from age-related macular degeneration[J]. Adv Pharmacol,1997, 38: 537-556.
[9] SNODDERLY D M, BROWN P K, DELORI F C, et al. The macular pigment. I. Absorbance spectra, localization, and discrimination from other yellow pigments in primate retinas[J]. Invest Ophthalmol Vis Sci, 1984, 25(6): 660-673.
[10] VAN DER VEEN R L, BERENDSCHOT T T, MAKRIDAKI M, et al. Correspondence between retinal reflectometry and a flicker-based technique in the measurement of macular pigment spatial profiles[J]. J Biomed Opt, 2009, 14(6): 64046.
[11] BEATTY S, MURRAY I J, HENSON D B, et al. Macular pigment and risk for age-related macular degeneration in subjects from a Northern European population[J]. Invest Ophthalmol Vis Sci,2001, 42(2): 439-446.
[12] DELORI F C, GOGER D G, HAMMOND B R, et al. Macular pigment density measured by autofluorescence spectrometry: comparison with reflectometry and heterochromatic
flicker photometry[J]. J Opt Soc Am A Opt Image Sci Vis, 2001, 18(6): 1212-1230.
[13] MELLERIO J, AHMADI-LARI S, VAN KUIJK F, et al. A portable instrument for measuring macular pigment with central fixation[J]. Curr Eye Res, 2002, 25(1): 37-47.
[14] ZAGERS N P, POT M C, VAN NORREN D. Spectral and directional reflectance of the fovea in diabetes mellitus: photoreceptor integrity, macular pigment and lens[J]. Vision Res, 2005, 45(13): 1745-1753.
[15] 裴非, 陶玉婷. Web数据挖掘与图书馆信息个性化服务: 吉林省科技情报学会2010年学术年会[Z]. 长春: 20101-5.
[16] DAVIES N P, MORLAND A B. Color matching in diabetes: optical density of the crystalline lens and macular pigments [J]. Invest Ophthalmol Vis Sci,2002, 43(1): 281-289.
[17] LIMA V C, ROSEN R B, MAIA M, et al. Macular pigment optical density measured by dual-wavelength autofluorescence imaging in diabetic and nondiabetic patients: a comparative study[J]. Invest Ophthalmol Vis Sci, 2010, 51(11): 5840-5845.
[18] FORD E S, WILL J C, BOWMAN B A, et al. Diabetes mellitus and serum carotenoids: findings from the Third National Health and Nutrition Examination Survey[J]. Am J Epidemiol,1999, 149(2): 168-176.
[19] PIPIS A, TOULIOU E, AUGUSTIN A J. Macular pigment optical density in a Central European population[J]. Ophthalmic Surg Lasers Imaging Retina, 2013, 44(3): 260-267.
[20] LIEW S H, GILBERT C E, SPECTOR T D, et al. Heritability of macular pigment: a twin study[J]. Invest Ophthalmol Vis Sci, 2005, 46(12): 4430-4436.
[21] HAMMOND C J, LIEW S H, VAN KUIJK F J, et al. The heritability of macular response to supplemental lutein and zeaxanthin: a classic twin study[J]. Invest Ophthalmol Vis Sci, 2012, 53(8): 4963-4968.
[22] 聂景蓉, 戴桂祥, 谭章喜, 等. 血脂与糖尿病视网膜病变的相关性研究[J]. 山东医药, 2006, 46(7): 32-33.
[23] 董宁, 褚利群, 肖林, 等. 糖尿病患者黄斑色素密度的相关因素分析[J]. 实用医学杂志, 2012, 28(2): 243-245.