原发性闭角型青光眼晶状体悬韧带松弛度与房角关闭的关系

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摘要目的：探讨原发性闭角型青光眼晶状体悬韧带松弛度在房角关闭发病中的作用。方法：选取2015年3月至2016年1月温州医科大学附属眼视光医院原发性急性闭角型青光眼患者17例（24眼）、原发性慢性闭角型青光眼患者5例（10眼）和可疑房角关闭患者6例（12眼）。使用Lenstar和超声生物学显微镜分别在缩瞳后和散瞳后测量晶状体位置、小梁网睫状突夹角，以二者的变化值间接反映悬韧带的松弛程度。结果：3组间缩、散瞳后的前房深度、晶状体厚度、晶状体位置变化差异无统计学意义（P＞0.05）。原发性急性闭角型青光眼发作眼和对侧眼之间的前房深度、晶状体厚度、晶状体位置变化差异无统计学意义（P＞0.05）。原发性急性闭角型青光眼小梁网睫状突夹角（TCPA）变化比原发性慢性闭角型青光眼和可疑房角关闭大（P＜0.001），原发性慢性闭角型青光和可疑房角关闭间的TCPA变化差异无统计学意义（P＞0.05）；原发性急性闭角型青光眼发作眼6点位置的TCPA变化小于对侧眼，差异有统计学意义（P=0.044）。结论：原发性急性闭角型青光眼存在一定的晶状体悬韧带松弛。

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	彭显耀
	孙瑞竹
	江俊宏
	吕帆
	梁远波

关键词 ：青光眼, 闭角型；晶体；悬韧带

Abstract：Objective: To explore the influence of relaxation of zonule in the pathogenesis of primary angle closure glaucoma. Methods: Seventeen subjects with primary acute angle-closure glaucoma (24 eyes), five subjects with primary chronic angle-closure glaucoma (10 eyes) and six subjects with angle-closure suspect (12 eyes) were enrolled in this study. The changes of anterior chamber depth (△ACD), lens thickness (△LT), lens position (△LP), trabecular-ciliary process angle (△TCPA) after myotic and mydriatict were measured by Lenstar and ultrasound biomicroscopy. The △LP and △TCPA could reflex the relaxation of zonule. Results: The differences of △ACD, △LT, △LP between the three groups were not significant (P>0.05). The differences of △ACD, △LT, △LP between the fellow eye and the acute eye in acute angle-closure glaucoma were not significant (P>0.05). The △TCPA of primary acute angle-closure glaucoma were larger than that of another two groups (P<0.001). But the differences of △TCPA between primary chronic angle-closure glaucoma and angle-closure suspect were not significant (P>0.05). The △TCPA of the acute eye in 6 o’clock was smaller than that of the fellow eye in acute angle-closure glaucoma (P=0.044). Conclusion: The weaken zonule maybe exist in primary acute angle-closure glaucoma in a certain extent.

Key words： glaucoma, angle-closure lens, crystalline zonule

收稿日期: 2016-07-11

基金资助:温州医科大学人才科研启动基金（QTJ13009）

通讯作者: 吕帆，教授，Email：lufan@mail.eye.ac.cn

作者简介: 彭显耀（1990-），男，安徽广德人，住院医师，硕士

链接本文:

https://xb.wmu.edu.cn/CN/ 或 https://xb.wmu.edu.cn/CN/Y2017/V47/I8/590

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