Evaluation of the inhibitory action and toxicity of elemene liposome combining ultrasound cavitation on the ectopic tumor of the nude mice model
WANG Jianzhong1, XU Yi2, LIU Pengcheng1, CHEN Haobo1
1.Department of Oncology, Wenzhou Traditional Chinese Medicine Hospital Affiliated to Zhejiang Chinese Medicine University, Wenzhou, 325000; 2.Department of Pharmacy, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015
WANG Jianzhong,XU Yi,LIU Pengcheng, et al. Evaluation of the inhibitory action and toxicity of elemene liposome combining ultrasound cavitation on the ectopic tumor of the nude mice model[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2017, 47(8): 571-575.
Abstract： Objective: To evaluate the inhibitory action and toxicity of elemene liposome (EL) combining ultrasonic cavitation on the entopic tumor for the nude mice model. Methods: The inhibitory efficacy was studied using C6 cells bearing armpit tumor model. Mice were assigned to 5 groups (n=7) as follows: group 1 for saline, group 2 for EL, group 3 for EL+MB, group 4 for EL+US and group 5 for EL+MB+US. Mice were administered via tail vein at the dosage of 50 mg/kg amount to 0.1 mL/10 g (injection solution/mice weight), 1 time per 2 d, 3 times in all. Tumor volume, tumor weight change, body weight growth rate were all measued. The white blood cell count (WBC) at the end point was also tested. Results: Compared with EL, EL+MB+US showed higher tumor growth inhibition, fewer mice body weight change and white blood count change (P<0.05) in the armpit tumor model. Conclusion: With better anti-tumor activity and lower blood toxicity, EL+MB+US may be developed as a new cancer targeted delivery system.
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