The immune response of Th17 cells in the cervical diseases with high-risk human papillomavirus infection
XUE Jisen1, ZHU Hua1, ZHANG Shenghui2, LYU Jieqiang3, HU Yan1
1.Department of Gynecology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015; 2.Department of Hematology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015; 3.Department of Gynecology, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325027
XUE Jisen,ZHU Hua,ZHANG Shenghui, et al. The immune response of Th17 cells in the cervical diseases with high-risk human papillomavirus infection[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2017, 47(7): 504-509.
Abstract：Objective: To study the role of cellular immunity in patients of cervical cancer with high-risk human papillomavirus (HPV) infection mediated by Th17 cells and IL-17. Methods: The study groups included 28 cervical cancer patients, 29 CIN3 patients, 30 CIN2 patients, 26 CIN1 patients, 25 high-risk HPV infected healthy women and 30 patients with HPV negative. The percentage of Th17 cells in the peripheral blood was detected by flow cytometry. The concentration of IL-17 in serum was examined by ELISA. Results: During the disease progression of cervical lesions, the proportion of Th17 cells in the total CD4+ cells showed a gradually increased tendency compared with the controls. The proportions differed significantly among the study groups and the control group (P<0.05). During the disease progression of cervical lesions, levels of IL-17 in serum showed a gradually increased tendency and differed significantly among all groups (P<0.05), but comparisons between any two groups were no significant difference (P>0.05). Conclusion: This study indicates that the cellular immunoreaction mediated by Th17 cells and IL-17 may be related to the infection of high-risk HPV, which contributes to the disease progression of its associated cervical diseases.
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