应用光学相干断层扫描血管成像技术分析近视眼黄斑区微血管变化

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摘要目的：应用光学相干断层扫描血管成像技术（OCTA）研究近视眼黄斑区视网膜微血管的变化及其与视网膜厚度的相关性。方法：2015年6月至2016年5月在温州医科大学附属眼视光医院就诊的患者45例（90眼）纳入研究，其中低度近视及正视眼组15例（30眼）作为对照组，中度近视组15例（30眼）、高度近视组15例（30眼）。采集黄斑区微血管密度及视网膜厚度，通过自动分层获得视网膜表层和深层血管图。选取以黄斑中心凹（fovea）为中心直径1 mm圆和3 mm旁中心（parafovea）圆环内血管密度进行分析。结果：Fovea处表层微血管密度和深层微血管密度均与眼轴呈正相关（r=0.51、0.52，P＜0.05）。Parafovea处表层微血管密度与眼轴呈负相关（r=-0.34，P=0.01），其深层微血管密度与眼轴无相关性（r=-0.03，P=0.79）。Fovea处表层微血管密度和深层微血管密度均与fovea处视网膜内五层厚度呈显著正相关（r=0.85、0.82，P＜0.05）。Parafovea处表层微血管密度和深层微血管密度均与parafovea处视网膜内五层厚度无相关性（r= 0.16、0.07，P＞0.05）。结论：随着眼轴的增加和视网膜厚度的增加，fovea处视网膜微血管密度会随之增加，而在parafovea区域，表层视网膜微血管密度会随着眼轴的增加而减少，但与视网膜厚度的变化并无相关性。临床上在应用血管成像技术时应考虑近视眼本身对黄斑区微血管的影响。

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关键词 ：光学相干断层扫描血管成像技术, 近视, 黄斑, 微血管密度, 视网膜

Abstract：Objective: To explore the alterations of myopic macular retinal capillaries and its correlation with retinal thickness using optical coherence tomography angiography (OCTA). Methods: Ninety eyes of 45 people were included in this study, divided into low myopia and emmetropia group 30 eyes of 15 people (control group), moderate myopia group 30 eyes of 15 people, high myopia group 30 eyes of 15 people. Acquisition of macular micro-vascular density and retinal thickness, then obtained the superficial and deep vascular graph by automatic stratification. The densities of 1 mm circle (fovea) and 3 mm circle ring (parafovea) in the center of macular fovea were analyzed using the built-in software. Results: There was a significant positive correlation between foveal superficial/deep density and the axial length (r=0.51, 0.52, P<0.05). There was a significant negative correlation between parafoveal superficial density and axial length (r=-0.34, P=0.01), but no significant correlation between parafoveal deep density and axial length (r=-0.03, P=0.79). There was a significant positive correlation between foveal superficial/deep density and the inner five-layer thickness of fovea (r=0.85, 0.82, P<0.05). There was no significant correlation between parafoveal superficial/deep density and the inner five-layer thickness of parafovea (r=0.16, 0.07, P>0.05). Conclusion: The density of retinal blood vessels in macular fovea will increase with increasing axial length and retinal thickness, while the density of retinal blood vessels will decrease with increasing of axial length but not directly related with the change of retina thickness in retinal parafovea. Clinical application of blood flow imaging technology should be taken account into myopia on the macular micro vascular impact.

Key words： optical coherence tomography angiography myopia macula microvasculature density retina

收稿日期: 2016-11-28

基金资助:浙江省自然科学基金资助项目（LY17H120005）；温州市公益性科技计划项目（Y20160442）。

通讯作者: 陈浩，教授，博士生导师，Email：chenhao@mail.eye.ac.cn

作者简介: 冯立淼（1989-），男，安徽滁州人，硕士生。

链接本文:

https://xb.wmu.edu.cn/CN/ 或 https://xb.wmu.edu.cn/CN/Y2017/V47/I6/391

[1] MIDELFART A, MIDELFART S. Prevalence of refractive errors among adults in Europe[J]. Arch Ophthalmol, 2005,123(4): 580.
[2] Kempen J H, Mitchell P, Lee K E, et al. The prevalence of refractive errors among adults in the United States, Western Europe, and Australia[J]. Arch Ophthalmol, 2004,122(4): 495-505.
[3] ROSE K, SMITH W, MORGAN I, et al. The increasing prevalence of myopia: implications for Australia[J]. Clin Exp Ophthalmol, 2001, 29(3): 116-120.
[4] Sawada A, Tomidokoro A, Araie M, et al. Refractive errors in an elderly Japanese population: the Tajimi study [J]. Ophthalmology, 2008, 115(2): 363-370.
[5] WONG T Y, FOSTER P J, HEE J, et al. Prevalence and risk factors for refractive errors in adult Chinese in Singapore[J]. Invest Ophthalmol Vis Sci, 2000, 41(9): 2486-2494.
[6] PAN C W, WONG T Y, LAVANYA R, et al. Prevalence and risk factors for refractive errors in Indians: the Singapore Indian Eye Study (SINDI)[J]. Invest Ophthalmol Vis Sci,2011, 52(6): 3166-3173.
[7] Holden B A, Fricke T R, Wilson D A, et al. Global prevalence of myopia and high myopia and temporal trends from 2000 through 2050[J]. Ophthalmology, 2016, 123(5):1036-1042.
[8] WANG X, KONG X, JIANG C, et al. Is the peripapillary retinal perfusion related to myopia in healthy eyes? A prospective comparative study[J]. BMJ Open, 2016, 6(3): e010791.
[9] YANG Y, WANG J, JIANG H, et al. Retinal microvasculature alteration in high myopia[J]. Invest Ophthalmol Vis Sci, 2016, 57(14): 6020-6030.
[10] LI H, MITCHELL P, LIEW G, et al. Lens opacity and refractive influences on the measurement of retinal vascular fractal dimension[J]. Acta Ophthalmol, 2010, 88(6): e234-240.
[11] SHIMADA N, OHNO-MATSUI K, HARINO S, et al. Reduction of retinal blood flow in high myopia[J]. Graefes Arch Clin Exp Ophthalmol, 2004, 242(4): 284-288.
[12] ZHAO Z, ZHOU X, JIANG C, et al. Effects of myopia on different areas and layers of the macula: a Fourier-domain optical coherence tomography study of a Chinese cohort[J].BMC Ophthalmol, 2015, 15: 90.
[13] NAKANISHI H, AKAGI T, HANGAI M, et al. Effect of axial length on macular ganglion cell complex thickness and on early glaucoma diagnosis by spectral-domain optical coherence tomography[J]. J Glaucoma, 2016, 25(5): e481-490.
[14] LI M, YANG Y, JIANG H, et al. Retinal microvascular network and microcirculation assessments in high myopia[J].Am J Ophthalmol, 2017, 174: 56-67.
[15] LIM L S, CHEUNG C Y, LIN X, et al. Influence of refractive error and axial length on retinal vessel geometric characteristics[J]. Invest Ophthalmol Vis Sci, 2011, 52(2): 669-678.
[16] KANEKO Y, MORIYAMA M, HIRAHARA S, et al. Areas of nonperfusion in peripheral retina of eyes with pathologic myopia detected by ultra-widefield fluorescein angiography [J]. Invest Ophthalmol Vis Sci, 2014, 55(3): 1432-1439.
[17] KUR J, NEWMAN E A, CHAN-LING T. Cellular and physiological mechanisms underlying blood flow regulation in the retina and choroid in health and disease[J]. Prog Retin Eye Res, 2012, 31(5): 377-406.