支气管哮喘与花生四烯酸脂氧酶代谢及其调控机制

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摘要半胱氨酸白三烯（CysLTs）和脂氧素（LXs）均是花生四烯酸脂氧酶（LO）途径代谢的重要产物，而LXs具有拮抗CysLTs的作用，目前两者在支气管哮喘发病机制中的作用已经得到基本肯定。5-LO和15-LO作为关键酶，其表达水平和活性与CysLTs和LXs的生成密切相关。影响LO的代谢因素包括细胞内Ca2+水平、MAPK信号传导通路、糖皮质激素等。笔者通过探讨造成CysLTs和LXs不平衡状态的各种影响因素，研究支气管哮喘的发病与缓解的病理生理机制，为支气管哮喘的临床防治提供依据。

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	卓乐盈
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	吴镇杰
	蔡畅

关键词 ：哮喘, 上皮细胞, 白三烯, 脂氧酶, 综述

收稿日期: 2016-04-27

基金资助:国家自然科学基金资助项目（81470225）。

通讯作者: 蔡畅，副主任医师，Email：rudy199@sina.cn。

作者简介: 卓乐盈（1992-），女，浙江温州人，硕士生。

链接本文:

https://xb.wmu.edu.cn/CN/ 或 https://xb.wmu.edu.cn/CN/Y2017/V47/I5/383

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