LYU Kejun. Relationship between microvascular density, micro lymphatic vessel density and clinicopathological characteristics of breast cancer[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2017, 47(5): 376-379.
Abstract：Objective: To detect the expressions of microvascular density (MVD) and micro lymphatic vessel density (LVD) in breast cancer tissues, investgate the relationship between MVD, LVD and clinical pathological features of breast cancer. Methods: A total of 60 cases of breast cancer patients were selected as the patients group, and 60 cases of proliferative diseases of mammary gland patients were selected as the control group. By adopting D2-40 marker of lymphatic endothelial cells and CD34 marker of vascular endothelial cells, breast cancer MVD and LVD were counted separately under a microscope. The relationship between expressions of MVD, LVD and clinical pathological features also were analyzed the relationship between expressions of MVD, LVD of breast cancer patients. Results: In the patients group, the average value of LVD was (5.32±3.81), and the average MVD was (65.34±24.18). The protein expression level of D2-40 and CD34 in the patients group was significantly higher than that of the control group (P<0.05), there is no correction of patients’ age with LVD and MVD (P>0.05), there was correction of tumor size, clinical stage, lymph node metastasis with LVD and MVD (P<0.05), and MVD and LVD were positively correlated (r=0.684, P<0.05). There was no significant difference in survival time between higher LVD group and lower LVD group, higher MVD group and lower MVD group (P>0.05). Conclusion: LVD and MVD are closely related with tumor diameter, clinical stage and lymph node metastasis in breast cancer patients, and no significant correlation with prognosis, which was closely related to breast cancer recurrence and distant metastasis.
