前列腺增生后不稳定膀胱致逼尿肌肌聚糖表达变化

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摘要目的：探讨良性前列腺增生（BPH）后不稳定膀胱导致膀胱逼尿肌肌聚糖（SG）表达变化。方法：对BPH后稳定膀胱组患者34例、BPH后不稳定膀胱组患者26例，采用免疫组织化学染色法、Western blot法检测膀胱壁逼尿肌中SG的α、β、γ 3种亚基蛋白表达情况，RT-PCR法检测SG的α、β、γ 3种亚基mRNA表达水平。结果：SG在BPH后不稳定膀胱组的平均表达水平较稳定膀胱组增加，差异有统计学意义（P＜0.05)。
结论：BPH后膀胱逼尿肌不稳定性可能与SG改变有关。

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	木海琦
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	陈映鹤

关键词 ：良性前列腺增生, 不稳定膀胱, 肌聚糖

Abstract：Objective: To study the expression change of sarcoglycan (SG) in the detrusor muscle of the unstable bladder caused by benign prostatic hyperplasia (BPH). Methods: 34 cases of stable bladder and 26 cases of unstable bladder were included in this study. The expressions of α-SG, β-SG, γ-SG in detrusor muscle of bladder were detected by immunohistochemical technique Western-blot and RT-PCR. Results: Compared to the group of stable bladder, the expression of SG in detrusor muscle of unstable bladder caused by BPH was increased (P<0.05). Conclusion: The changes of SG in the detrusor muscle of bladder may closely related to the production of unstable bladder caused by BPH.

Key words： benign prostatic hyperplasia unstable bladde sarcoglycan

收稿日期: 2016-06-13

基金资助:

温州市公益性科技计划项目（Y20150219）。

通讯作者: 陈映鹤，主任医师，Email：chenyh@wzhealth.com。

作者简介: 木海琦（1982-），男，浙江温州人，主治医师，硕士。

链接本文:

https://xb.wmu.edu.cn/CN/ 或 https://xb.wmu.edu.cn/CN/Y2017/V47/I5/366

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