The effects of high frequency repetitive transcranial magnetic stimulation on executive function and oxidative stress in patients with alcohol dependence
Liu Linjing, Pan Jianshe, Zhu Cheng, Zheng Ke, Liu Jiahong, Ye Minjie.
Department of Psychiatry, Kangning Hospital Affiliated to Wenzhou Medical Univeristy, Wenzhou, 325007
Liu Linjing,Pan Jianshe,Zhu Cheng, et al. The effects of high frequency repetitive transcranial magnetic stimulation on executive function and oxidative stress in patients with alcohol dependence[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2017, 47(5): 347-351.
Abstract：Objective: To investigate the effects of high frequency repetitive transcranial magnetic (rTMS) on the executive function and oxidative stress in patients with alcohol dependence, and to analyze the relationship between the changes of executive function and the changes of oxidative stress during the treatment process. Methods: Two hundreds patients with alcohol dependence after withdrawal period (stop drinking more than 14 days) were randomly divided into real rTMS group and sham rTMS group according to the visiting number. The patients in real rTMS group were treated with 10 Hz rTMS for 4 weeks, while the patients in sham rTMS group were given the same degree of pseudo stimulation. The oxidative stress level of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and malondialdehyde (MDA) and the score of behavior rating inventory of executive function-adult version (BRIEF-A) were measured before and after 4 weeks’ treatments in patients with alcohol dependence. The data of two groups were collected and analyzed by SPSS20.0. Results: Before the treatment, the BRIEF-A total score and its factor score and the serum level of SOD, GSH-Px and MDA between real rTMS group and sham rTMS group had no significant differences (P>0.05); After 4 weeks’ treatments, the BRIEF-A total score and its factor score and the serum level of MDA in real rTMS group were much lower than that of sham rTMS group and that of before treatments, while the serum level of SOD and GSH-Px in real rTMS group was much higher than that of sham rTMS group and that of before treatments. Compared to the sham rTMS group, the changes of BRIEF-A total score and its factor score and the level of oxidative stress in real rTMS group were significantly higher (P<0.05); The change level of MAD and GSH-Px were positively correlated with the the changes of BRIEF-A total score and its factor score, while the change level of MAD and GSH-Px could explain 21.30% and 7.10% of the reduction of BRIEF-A total score respectively (P<0.05). Conclusion: High frequency rTMS can significantly improve the executive function and change the level of oxidative stress in patients with alcohol dependence. The changes of MAD and GSH-Px level may be closely related to the improvement of executive function during treatment of rTMS.
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