外周血中性粒细胞/淋巴细胞比值与糖尿病患者下肢动脉病变的相关性

摘要
图/表
参考文献
相关文章 (0)

全文: PDF (1294 KB) HTML (1 KB)
输出: BibTeX | EndNote (RIS)

摘要目的：探讨外周血中性粒细胞/淋巴细胞比值（NLR）与2型糖尿病（T2DM）患者下肢动脉病变（LEAD）的相关性。方法：选取T2DM患者627例，测定患者外周血白细胞计数、淋巴细胞计数、中性粒细胞计数，计算NLR，将NLR按四分位数分为4组：Q1组：NLR≤1.30，159例；Q2组：NLR为1.31～1.81，154例；Q3组：NLR为1.82～2.50，156例；Q4组：NLR≥2.51，158例。研究NLR与T2DM患者LEAD的相关性。结果：经logistic回归分析，与Q1组相比，Q3、Q4组LEAD发病率明显升高，其OR（95%CI）分别为1.62（1.03～2.55）、1.84（1.17～2.90）（P=0.037，P=0.008）；在调整一般资料及生化指标后，Q4组LEAD发病率仍明显升高，其OR（95%CI）为1.75（1.04～2.92）（P=0.034）。结论：随着外周血NLR升高，T2DM患者LEAD的发生率增加。

	服务
	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章
	商书霞
	宋光耀
	于冬
	段丽君
	贺敬丰
	郭丽

关键词 ：中性粒细胞/淋巴细胞比值；踝肱指数；炎症反应；糖尿病, 2型；下肢动脉病变

Abstract：Objective: To investigate the relationship between neutrophil-to-lymphocyte ratio (NLR) and lower extremity arterial disease (LEAD) in T2DM patients. Methods: Six hundred and twenty-seven inpatients with T2DM were recruited in this study. The numbers of the white blood cell, neutrophils (N) and lymphocytes (L) as well as the NLR values of peripheral blood were detected. Based on the quartile of NLR, all patients were divided into four groups: Q1≤1.30 (n=159), Q2: 1.31-1.81 (n=154), Q3: 1.82-2.50 (n=156) and Q4≥2.51 (n=158). The relationship between NLR and LEAD in T2DM patients was discussed. Results: Logistic regression analysis showed the prevalence of LEAD was significant higher in Q3 (OR: 1.62, 95%CI: 1.03-2.55, P=0.037) and Q4 (OR: 1.84, 95%CI: 1.17-2.90, P=0.008) than that in Q1. After adjusting clinical characters and biochemical, the prevalence of LEAD was still higher in Q4 (OR: 1.75, 95%CI: 1.04-2.92, P=0.034). Conclusion: The prevalence of LEAD in T2DM patients increases with the rise of NLR.

Key words： neutrophil-to-lymphocyte ratio ankle brachial index inflammatory reaction diabetes mellitus, type 2 lower extremity arterial disease

收稿日期: 2016-04-25

基金资助:河北省医学科学研究重点课题（20160744）。

通讯作者: 宋光耀，主任医师，Email：sguangyao2@163.com。

作者简介: 商书霞（1973-），女，河北邯郸人，副主任医师，硕士。

链接本文:

https://xb.wmu.edu.cn/CN/ 或 https://xb.wmu.edu.cn/CN/Y2017/V47/I4/286

[1] YAHAGI K, KOLODGIE F D, LUTTER C, et al. Pathology of human coronary and carotid artery atherosclerosis and vascular calcification in diabetes mellitus[J]. Arterioscler Thromb Vasc Biol, 2017, 37(2): 191-204.
[2] AVCI A, ELNUR A, GOKSEL A, et al. The relationship between neutrophil/lymphocyte ratio and calcific aortic stenosis[J]. Echocardiography, 2014, 31(9): 1031-1035.
[3] FARAH R, KHAMISY-FARAH R. Association of neutrophil to lymphocyte ratio with presence and severity of gastritis due to Helicobacter pylori infection[J]. J Clin Lab Anal, 2014, 28(3): 219-223.
[4] BEKLER A, ERBAG G, SEN H, et al. Predictive value of elevated neutrophil-lymphocyte ratio for left ventricular systolic dysfunction in patients with non ST-elevated acute coronary syndrome[J]. Pak J Med Sci, 2015, 31(1): 159-163.
[5] HUANG W, HUANG J, LIU Q, et al. Neutrophil-lymphocyte ratio is a reliable predictive marker for early-stage diabetic nephropathy[J]. Clin Endocrinology(Oxf), 2015, 82(2): 229-233.
[6] TEPERMAN J, CARRUTHERS D, GUO Y, et al. Relationship between neutrophil-lymphocyte ratio and severity of lower extremity peripheral artery disease[J]. Int J Cardiol, 2017, 228(1): 201-204.
[7] 李小鹰, 管珩, 杨庭树. 下肢动脉粥样硬化性疾病诊治中国专家建议(2007)[J]. 中华老年医学杂志, 2007, 26(10):725-740.
[8] Balta S, Ozturk C, Balta I, et al. The neutrophil-lymphocyte ratio and inflammation[J]. Angiology, 2016, 67(3): 298-299.
[9] BALTA S, CELIK T, MIKHAILIDIS D P, et al. The relation between atherosclerosis and the neutrophil-lymphocyte ratio[J]. Clin Appl Thromb Hemost, 2016, 22(5): 405-411.
[10] YILMAZ G, SEVINC C, USTUNDAG S, et al. The relationship between mean platelet volume and neutrophil/lymphocyte ratio with inflammation and proteinuria in chronic kidney disease[J]. Saudi J Kidney Dis Transpl, 2017, 28(1): 90-94.
[11] VERDOIA M, SCHAFFER A, BARBIERI L. et al. Impact of diabetes on neutrophil-to-lymphocyte ratio and its relationship to coronary artery disease[J]. Diabetes Metab, 2015, 41(4): 304-311.
[12] SHINY A, BIBIN Y S, SHANTHIRANI C S, et al. Association of neutrophil-lymphocyte ratio with glucose intolerance: an indicator of systemic inflammation in patients with type 2 diabetes[J]. Diabetes Technol Ther, 2014, 16(8): 524-530.
[13] SEFIL F, ULUTAS K T, DOKUYUCU R, et al. Investigation of neutrophil lymphocyte ratio and blood glucose regulation in patients with type 2 diabetes mellitus[J]. J Int Med Res, 2014, 42(2): 581-588.
[14] LOU M, LUO P, TANG R, et al. Relationship between neutrophil-lymphocyte ratio and insulin resistance in newly diagnosed type 2 diabetes mellitus patients[J]. BMC Endocr Disord, 2015, 15(1): 9.
[15] TANINDI A, ERKAN A F, ALHAN A, et al. Arterial stiffness and central arterial wave reflection are associated with serum uric acid, total bilirubin, and neutrophil-to-lymphocyte ratio in patients with coronary artery disease[J]. Anatol J Cardiol, 2015, 15(5): 396-403.
[16] SAITO Y, TAKAHASHI I, IWANE K, et al. The influence of blood glucose on neutrophil function in individuals without diabetes[J]. Luminescence, 2013, 28(4): 569-573.