A Meta-analysis of flurbiprofen axetil versus tramadol in postoperative analgesia effect and adverse drug reactions
ZOU Liangwang1, ZHAO Xiyue2, QIU Enyi3, XU Lijuan2, SHAN Yunfeng2.
1.Department of Surgery, Wenzhou Longwan First People’s Hospital, Wenzhou, 325024; 2.Department of Anesthesiology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015; 3.Department of Radiotherapy and Chemotherapy, Wenzhou Central Hospital, Wenzhou, 325000
ZOU Liangwang,ZHAO Xiyue,QIU Enyi, et al. A Meta-analysis of flurbiprofen axetil versus tramadol in postoperative analgesia effect and adverse drug reactions[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2017, 47(3): 206-210.
Abstract：Objective: To compare and analyze flurbiprofen axetil with tramadol in postoperative analgesic effect and the occurrence of adverse drug reactions. Methods: All the randomized controlled trials referring to the comparison of flurbiprofen axetil and tramadol in postoperative analgesia effect and adverse drug reactions were searched in the domestic and foreign databases (such as CNKI, WanFang database, Medline and Pubmed) in January 2006 to May 2015. The enrolled published literatures were analyzed using Meta-analysis method with RevMan 5.1 statistical analysis software. Results: Ten separate clinical randomized controlled trials including 728 cases were researched with the Meta-analysis. Objective responsiveness: there is no significant difference between the postoperative analgesia effect of flurbiprofen axetil group and that of tramadol group; But in the adverse drug reactions: the incidence of nauses and vomiting were lower in the flurbiprofen axetil group than that in the tramadol group (P<0.001), the RR and 95%CI were 0.36 (0.26-0.50). The incidence of dizziness was lower in the flurbiprofen axetil group than that in the tramadol group (P=0.01), the RR and 95%CI were 0.46 (0.26-0.83). The funnel plots showed no significant publication bias in each indexes. Conclusion: The roles of postoperative analgesia effect in flurbiprofen axetil group are similar to tramadol group, but the incidence of adverse drug reactions are less in the flurbiprofen axetil group than that in the tramadol group.
