单磷酸腺苷活化蛋白激酶调控细胞自噬的机制研究进展

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摘要自噬是细胞对外界环境应激所作出的反应，是细胞降解自身成分以维持细胞活性和生存的过程。在动物组织中，自噬机制的缺陷通常和细胞衰老、年龄相关性退化性疾病有关联，这些疾病包括心血管疾病、癌症、免疫系统功能受损和神经系统病变等。目前已经发现，许多蛋白可以对能量、营养和生长因子水平以及应激做出反应，其中包括一些激酶，它们可以正向或负向调节自噬过程以调节细胞对外界环境的适应性。最近研究表明细胞可以通过单磷酸腺苷活化蛋白激酶（AMPK）对上述适应反应发挥重要作用，本文就近些年有关AMPK对自噬调控机制的研究成果作一综述。

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	桂迪
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关键词 ：单磷酸腺苷活化蛋白激酶, 哺乳动物雷帕霉素靶蛋白, ULK1, 自噬, 综述文献

收稿日期: 2016-02-26

基金资助:国家自然科学基金资助项目（81473406）；浙江省卫生厅平台计划研究重点资助项目（2012ZDA033）。

通讯作者: 黄晓颖，主任医师，副教授，Email：zjwzhxy@126.com。

作者简介: 桂迪（1985-），男，浙江慈溪人，硕士生。

链接本文:

https://xb.wmu.edu.cn/CN/ 或 https://xb.wmu.edu.cn/CN/Y2017/V47/I2/149

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