The case-control study of influencing factors for birth defects in Lishui
ZHANG Yali1, LAN Juhong1, LYU Zhuochao1, XIAO Lihua2
1.Department of Neonatal, Lishui Central Hospital, Lishui, 323000; 2.Department of Health Care, Lishui Maternal and Child Health Care Hospital, Lishui, 323000
ZHANG Yali,LAN Juhong,LYU Zhuochao, et al. The case-control study of influencing factors for birth defects in Lishui [J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2017, 47(1): 56-60.
Abstract：Objective: To investigate the risk factors of birth defects in Lishui city, and to provide scientific evidence for intervention. Methods: A 1:3 case-control study was conducted, 601 mothers of infants with birth defects and 1803 controls were investigated retrospectively. Risk factors were analyzed by multivariate Logistic regression. Results: The incidence of birth defects was 29.79‰, the former five types of birth defects were congenital heart disease, polydactyly, cleft lip, syndactyly and, microtia. Logistic regression showed that maternal age (OR=3.752, 95%CI: 1.247-11.293, P=0.019), the health condition in the first trimester of pregnancy (OR= 2.997, 95%CI: 1.084-8.287, P=0.034), smoking or passive smoking during pregnancy (OR=2.205, 95%CI: 1.088-4.470, P=0.028), exposure to toxic factors during pregnancy (OR=3.582, 95%CI: 2.071-4.983, P=0.047), and face-painting, dying fingernails and dying hair in pregnancy (OR=3.659, 95%CI: 2.064-6.488, P<0.001) were the risk factors. Conclusion: Maternal age, the health condition in the first trimester of pregnancy, smoking or passive smoking during pregnancy, exposure to toxic factors in pregnancy, and face-painting, dying fingernails and dying the hair in pregnancy are the risk factors of birth defects.
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