基于海马神经元组群的癫痫仿真模型研究进展

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摘要癫痫是一种严重危害人类健康的神经系统疾病，对此研究者们投入了大量的财力、人力和物力研究其发病机制。在实验基础上建立癫痫仿真模型有利于人们探索癫痫发病机制及研制抗癫痫药物。大量研究表明癫痫的发生与海马结构变化有密切关系，因此本文介绍了近年来国际上广泛研究的、基于生理解剖的海马神经元组群的癫痫仿真模型的研究工作，并结合我们目前的工作展望癫痫仿真模型的发展趋势。

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	郑茜茜
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关键词 ：癫痫, 仿真模型, 海马CA1区, 海马CA3区, 综述文献

收稿日期: 2016-04-05

基金资助:浙江省教育厅访问学者教师专业发展项目。

作者简介: 郑茜茜（1978-），女，浙江温州人，讲师，硕士。

链接本文:

https://xb.wmu.edu.cn/CN/ 或 https://xb.wmu.edu.cn/CN/Y2016/V46/I12/933

[1] LITT B, ECHAUZ J. Prediction of epileptic seizures[J]. Lancet Neurol, 2002, 1(1): 22-30.
[2] OIKAWA H, SASAKI M, TAMAKAWA Y, et al. The circuit of Papez in mesial temporal sclerosis: MRI[J]. Neuroradiology, 2001, 43(3): 205-210.
[3] HANEEF Z, LENARTOWICZ A, YEH H J, et al. Functional connectivity of hippocampal networks in temporal lobe epilepsy[J]. Epilepsia, 2014, 55(1): 137-145.
[4] ANDERSON P, MORRIS R, AMARAL D, et al. The hippocampus book[M]. New York and London: Oxford University Press, 2007: 37-43.
[5] FREUND T F, BUZSAKI G. Interneurons of the hippocampus[J]. Hippocampus, 1996, 6(4): 347-470.
[6] 岳伟, 张雅静, 管雅琳, 等. 内侧颞叶癫痫患者海马硬化的影像学研究[J]. 中国神经精神疾病杂志, 2014, 40(10): 607-611.
[7] BERTRAM E H. Temporal lobe epilepsy: Where do the seizures really begin?[J]. Epilepsy Behav, 2009, 14 Suppl 1: 32-37.
[8] YANG F, GONG X W, GONG H Q, et al. Microelectrode array recordings of excitability of low Mg2+-induced acute hippocampal slices[J]. Neural Regen Res, 2010, 5(20): 1548-1551.
[9] 尤竹燕, 王斌生, 解敏, 等. 白藜芦醇对大鼠海马CA1区诱发癫痫样放电的影响[J]. 中国药理学通报, 2012, 28(2): 260-265.
[10] HSIAO M C, YU P N, SONG D, et al. An in vitro seizure model from human hippocampal slices using multi-electrode arrays[J]. J Neurosci Methods, 2015, 244: 154-163.
[11] ANTONIO L L, ANDERSON M L, ANGAMO E A, et al. In vitro seizure like events and changes in ionic concentration[J]. J Neurosci Methods, 2016, 260: 33-44.
[12] SAFFARZADEH F, ESLAMIZADE M J, MOUSAVI S M, et al. TRPV1 receptors augment basal synaptic transmission in CA1 and CA3 pyramidal neurons in epilepsy[J]. Neuroscience, 2016, 314: 170-178.
[13] MCCORMICK D A, CONTRERAS D. On the cellular and network bases of epileptic seizures[J]. Annu Rev Physiol, 2001, 63: 815-846.
[14] CUTSURIDIS V, COBB S, GRAHAM B P. Encoding and retrieval in a model of the hippocampal CA1 microcircuit[J]. Hippocampus, 2010, 20(3): 423-446.
[15] 汪洋. 大鼠海马CA1区神经活动对体感刺激响应的研究[D]. 浙江: 浙江大学, 2014.
[16] RATNADURAI-GIRIDHARAN S, STEFANESCU R A, KHARGONEKAR P P, et al. Genesis of interictal spikes in the CA1: A computational investigation[J]. Front Neural Circuits, 2014, 8: 2.
[17] WEI Y, ULLAH G, INGRAM J, et al. Oxygen and seizure dynamics: II. Computational modeling[J]. J Neurophysiol, 2014, 112 (2): 213-223.
[18] KUNEC S, HASSELMO M E, KOPELL N. Encoding and retrieval in the CA3 region of the hippocampus: a model of theta-phase separation[J]. J Neurophysiol, 2005, 94(1): 70-82.
[19] NEYMOTIN S A, LAZAREWICZ M T, SHERIF M, et al. Ketamine disrupts theta modulation of gamma in a computer model of hippocampus[J]. J Neurosci, 2011, 31(32): 11733-11743.
[20] TRAUB R D, JEFFERYS J G R, WHITTINGTON M A. Enhanced NMDA conductance can account for epileptiform activity induced by low Mg2+ in the rat hippocampal slice [J]. J Physiol, 1994, 478Pt3: 379-393.
[21] REN H, SHI Y J, LU Q C, et al. The role of the entorhinal cortex in epileptiform activities of the hippocampus[J]. Theor Biol Med Model, 2014, 11: 14.
[22] HUMMOS A, FRANKLIN C C, NAIR S S. Intrinsic mechanisms stabilize encoding and retrieval circuits differentially in a hippocampal network model[J]. Hippocampus, 2014, 24(12): 1430-1448.
[23] MIZUSEKI K, SIROTA A, PASTALKOVA E, et al. Theta oscillations provide temporal windows for local circuit computation in the entorhinal-hippocampal loop[J]. Neuron,2009, 64(2): 267-280.
[24] CUTSURIDIS V, POIRAZI P. A computational study on how theta modulated inhibition can account for the long temporal windows in the entorhinal-hippocampal loop[J]. Neurobiol Learn Mem, 2015, 120: 69-83.
[25] SANDLER R A, SONG D, HAMPSON R E, et al. Hippocampal closed-loop modeling and implications for seizure stimulation design[J]. J Neural Eng, 2015, 12(5): 056017.
[26] KINOSHITA M, IKEDA A, MATSUHASHI M, et al. Electric cortical stimulation suppresses epileptic and background activities in neocortical epilepsy and mesial temporal lobe epilepsy[J]. Clin Neurophysiol, 2005, 116(6): 1291-1299.
[27] MELDRUM B S, AKBAR M T, CHAPMAN A G. Glutamate receptors and transporters in genetic and acquired models of epilepsy[J]. Epilepsy Res, 1999, 36(2-3): 189-204.
[28] EID T, LEE T S, WANG Y, et al. Gene expression of glutamate metabolizing enzymes in the hippocampal formation in human temporal lobe epilepsy[J]. Epilepsia, 2013, 54(2): 228-238.