Effect of mitochondrial aldehyde dehydrogenase 2 genotype on cardio-protection in patients with coronary artery bypass grafting
ZHANG Yujian1, DAI Yiru1,2, XIA Fangfang1, LIU Le1, XU Xuzhong1.
1.Department of Anesthesiology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015; 2.Department of Anesthesiology, Chinese Traditional and Western Medicine Hospital, Wenzhou, 325000
ZHANG Yujian,DAI Yiru,XIA Fangfang, et al. Effect of mitochondrial aldehyde dehydrogenase 2 genotype on cardio-protection in patients with coronary artery bypass grafting[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2016, 46(12): 901-904.
Abstract：Objective: To investigate the clinical effect of ALDH2*1 allele on cardio-protection of patients with coronary artery bypass grafting (CABG). Methods: Forty eight patients undergone simple CABG were divided into 2 group: ALDH2*1 (n=29) and ALDH2*2 (n=19), according to the results of ALDH2 gene SNP504 detection. 24 hours after operation, blood sample were taken for the measurement of cTnI, Mb, CK-MB and MDA. Postoperative mechanical ventilation time, ICU length of stay and postoperative 24 h cardiac drug use score were recorded. Results: There was no difference in the patient’s data among two groups, including age, body weight, ejection fractions and operation time. ALDH2*1 carriers showed lower cTnI, Mb, CK-MB and MDA, and shorter postoperative mechanical ventilation time, ICU length of stay and postoperative 24 h cardiac drug use score. Conclusion: ALDH2*1 allele protects against myocardium injury during open heart surgery cardiopulmonary bypass. The mechanism may be related to ALDH2 enzymes metabolism of toxic aldehydes.
