Expression and significance of tumor necrosis factor-alpha and interleukin-6 in juvenile nasopharyngeal angiofibroma
WU Xianmin1, YE Fan1, WU Peng1, CHEN Xiaoyun1, LIN Chang2, LIAO Zhisu1.
1.Department of Otorhinolaryngology and Head and Neck Surgery, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015; 2.Department of Otorhinolaryngology and Head and Neck Surgery, the First Affiliated Hospital of Fujian Medical University, Fuzhou, 350004
WU Xianmin,YE Fan,WU Peng, et al. Expression and significance of tumor necrosis factor-alpha and interleukin-6 in juvenile nasopharyngeal angiofibroma[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2016, 46(12): 887-890.
Abstract：Objective: To detect the expression of tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) in nasopharyngeal angiofibroma (JNA) and to explore the role of TNF-α and IL-6 in the mechnism of the bone destruction in JNA. Methods: The expressions of TNF-α and IL-6 in JNA tissue of 20 patients and normal inferior turbinate tissues in 10 cases of persons were determined by SP method of immunohistochemistry. Results: The positive expression rates of TNF-α and IL-6 proteins in JNA both were 90.0%, significantly higher than those in inferior turbinate tissues which both were 20.0% (P<0.01). The expressions of TNF-α and IL-6 protein were no correlation with the clinical stage of JNA (P>0.05). Conclusion: The higher expressions of TNF-α and IL-6 in JNA tissues may be the influence factors involved in bone destruction of the JNA.
