WANG Weiqian,ZHAO Yongzhong,DU Songmei, et al. Observation on the curative effect of tandospirone for the male sexual dysfunction induced by paroxetine[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2016, 46(11): 840-842,845.
Abstract：Objective: To investigate whether tandospirone can cure the male sexual dysfunction caused by paroxetine. Methods: Patients with the single treatment of paroxetine for more than 3 months were selected, evaluation of HAMA, HAMD-17 was adopted, HAMA score <7 points and HAMD score<7 points were choosed in the rehabilitation period patients, then Arizona Sexual Experience Scale (ASEX) was used. Eighty four patients whose ASEX score>19 were randomly divided into two groups, with 30 mg/d and 60 mg/d of tandospirone of each group. ASEX, IIEF-5 and sex life quality questionnaire (mSLQQ-QoL) before treatment were evaluated, treatment for 4 weeks and 8 weeks. The scale before and after treatment and the scale between groups were contrasted. Results: Compared with the total score of mSLQQ-QoL, the two groups’ total average in 4 weeks and 8 weeks all had been significantly increased (P<0.05), the two groups’ increased of total score of 30 mg/d and 60 mg/d had been significantly increased (P<0.01); comparison on the cure rate of sexual dysfunction, the 30 mg group was 56%, the 60 mg group was 62.5%, the two groups had no significant difference (x2=0.21, P=0.64). Conclusion: Tandospirone cure the sexual dysfunction caused by paroxetine has a certain therapeutic effect, and there is a certain dose-effect relationship.
