Clinical significance of CA-125 and CA19-9 levels in spontaneous ruptured ovarian endometrioma
HUANG Min1,2, LIN Feng2, ZHENG FeiYun2.
1.Department of Gynecology, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325027; 2.Department of Gynecology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015
HUANG Min,LIN Feng,ZHENG FeiYun.. Clinical significance of CA-125 and CA19-9 levels in spontaneous ruptured ovarian endometrioma[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2016, 46(11): 849-852.
Abstract：Objective: To explore the clinical roles of serum CA-125 and CA19-9 in women with spontaneous ruptured ovarian endometriomas. Methods: Retrospective data were collected from 50 women who were diagnosed as spontaneous ruptures ovarian endometriomas from January 2006 to October 2015. In addition, 70 women diagnosed with unruptured ovarian endometriomas were chosen to serve as control subjects. Serum CA-125 and CA19-9 levels, together with the clinical materials, were collected. Results: Serum CA-125, CA19-9, and the combined biomarkers were shown to be obviously elevated in the spontaneous ruptured ovarian endometrioma group (P<0.05). The AUC value of CA-125 was 0.966 (95%CI: 0.937-0.995), the sensitivity and specificity were 86.8%, 95.4%, and AUC value of CA19-9 was 0.939 (95%CI: 0.884-0.994), the sensitivity and specificity were 93.5% and 89.4%, respectively. The AUC value for the combined biomarkers was 0.992 (95%CI: 0.981-1.000), with a high sensitivity and specificity of 99.9% and 93.6%, respectively. Moreover, The diameter of the tumor in the rupture group (7.78±3.12) cm was greater than that in the non rupture group (5.80±1.63) cm (P<0.05). Conclusion: Serum CA-125 and CA19-9 are significantly increased in the patients with spontaneous ruptured ovarian endometriomas. Moreover, the combined CA-125 with CA19-9 is better than alone in the diagnosis of a spontaneous ruptured ovarian endometrioma.
