LU Xulian,LI Xiufang,ZHANG Haiyong, et al. The corrleation between the new lung adenocarcinoma classification and the EGFR mutation[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2016, 46(10): 769-772.
Abstract：Objective: To evaluate the correlation of EGFR mutation and histological subtypes of lung adenocarcinoma based on the IASLC/ATS/ERS classification 2011. Methods: 240 resected lung adenocarcinoma specimens were analyzed by ARMS, then the differences between histological subtypes and EGFR mutation were compared by the x2 test. Results: EGFR mutation was detected in 240 specmens, most of which were acinar and papillary predominant adenocarcinoma, 89% and 56% respectively. EGFR mutation rate of the specimens with acinar, lepidic, papillary, or micropapillary component was higher than that of without these components (P<0.05), and with solid or mucinous component was lower than that without the component (P<0.05). Conclusion: There is heterogeneity of EGFR mutation in lung adenocarcinoma. The presence of well-differentiated components in lung adenocarcinoma, such as acinar, micropapillary, papillary and lepidic, indicates a higher EGFR mutation rate, while the solid and mucinous component indicates a lower EGFR mutation rate.
