Association between serum triglyceride levels and cognitive function in depressive disorder
SHAO Tiannan1,2, HUI Li2, CHEN Qingjian3, YE Minjie2, GONG Benhong2, LIU Linjing2, CHEN Yuanling2, TANG Wenjie3.
1.The First Clinical Medical College, Wenzhou Medical University, Wenzhou, 325035; 2.Institute of Mental Health, Kangning Hospital Affiliated to Wenzhou Medical University, Wenzhou, 325007; 3.Wenzhou Medical University, Wenzhou, 325035
SHAO Tiannan,HUI Li,CHEN Qingjian, et al. Association between serum triglyceride levels and cognitive function in depressive disorder[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2016, 46(10): 752-755.
Abstract：Objective: To investigate whether there are the characteristics of cognitive impairments in depressive patients, and to further examine whether serum triglyceride levels are associated with cognitive impairments in depressive patients. Methods: Eighty-three depressive patients and 87 healthy controls were enrolled in a case-control study. Cognitive function was assessed by RBANS in all subjects. Serum triglyceride levels were measured in both two groups. Results: Multivariate analysis of covariance showed that there were significantly lower cognitive function on the RBANS total score, the language index score, and the delayed memory index score in depressive patients than healthy controls (P<0.01). For the patients, serum triglyceride levels were negatively associated with the RBANS total score (P<0.01), the language index score (P<0.05), the attention index score (P<0.05), and the delayed memory index score (P<0.01). Further multivariate regression analysis showed that serum triglyceride levels were associated with the RBANS total score (P<0.05), the attention index score (P<0.05), and the delayed memory index score (P<0.01). Conclusion: Depressive patients have poorer cognitive function, especially in language and delayed memory. Moreover, the higher levels of serum triglyceride can cause cognitive impairments including attention and delayed memory in depressive patients.
