CHEN Cong,FU Gangze,CHEN Yonghua, et al. The value of imaging characteristics on CT in the diagnosis of preinvasive lesions of lung adenocarcinoma[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2016, 46(10): 738-742.
Abstract：Objective: To analyze the computed tomography appearances of preinvasive leisions of lung adenocarcinoma and to improve the diagnosis of atypical adenomatous hyperplasia (AAH) and adenocarcinoma in situ (AIS). Methods: Twenty-eight cases of AAH and 57 cases of AIS confirmed pathologically were retrospectively recruited. Comparison of CT features of lung nodules in the two groups, including location, shape, margin, diameter, solid component, internal characteristics and mean CT attenuation. Results: The blood vessels through of focal ground glass nodule (fGGN), diameter and the mean CT attenuation were significantly different between the two diseases (P<0.05 for all), while no difference was found in the pattern of fGGN, location, shape, boundary, lobulation speculation and vacuole sign between AAH and AIS (P>0.05 for all). The average of diameters was (7.9±3.0) mm for AAH, which was smaller than (12.3±3.9) mm for AIS. The optimal cut-off value from the receiver characteristic (ROC) curve was 8.5 mm, with sensitivity of 82.5% and specificity of 71.4%. The mean CT attenuation was (-644±71) HU for AAH, which was smaller than (-492±87) HU for AIS. The optimal cut-off value from ROC was -549 HU, with sensitivity of 77.2% and specificity of 96.4%. Concluion: Comprehensive analysis of the pattern, size, density, shape and internal characteristics of fGGN is helpful for differential diagnosis of AAH and AIS.
