HU Wei,TANG Jun,GUO Xiaoshan, et al. The influence of zoledronic acid on the osteoporotic patients after total knee arthroplasty[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2016, 46(9): 687-690.
Abstract：Objective: To analyze the impact of zoledronic acid on patients suffering from osteoporosis after total knee arthroplasty (TKA). Methods: A retrospective study was conducted to 38 cases selected from patients in need of knee arthroplasty admitted from September 2009 to June 2013. Among these, 18 cases (study group) were given intravenous drip of zoledronic acid to 5 mg after knee arthroplasty; 20 cases (control group) were given the same amount of placebo, and closely observed for the subsequent reaction in infusion process. Their bone density was tested in preoperative and postoperative 3 months; meanwhile, new fractures in other parts or around prosthesis appearing during follow-up visits were recorded, as well as HSS function after surgery for TKA. Results: Bone density at the lumbar (L2-4), distal femur and proximal tibia (g/cm2) of study group are (0.642±0.059), (0.621±0.059) and (0.601±0.051), respectively; these of the control group are (0.654±0.062), (0.623±0.061) and (0.602±0.057), respectively. Three months later, these data of study group increased to (0.785±0.078), (0.797±0.064), (0.757±0.063), respectively; these data of control group respectively become (0.652±0.067), (0.621±0.059), (0.601±0.059), respectively. Comparison shows that preoperative and postoperative bone mineral density of the two groups has obvious statistical significance (P<0.05). Moreover, fracture incidence in other parts of study group and HSS score were 5.56% and 82.2 (points), respectively; those of the control group were 20% and 76.6 (points). Comparison of the two groups had significant statistical significance (P<0.05). Conclusion: The application of zoledronic acid to patients with osteoporosis after total knee arthroplasty is safe and effective, not only reducing incidence of fractures around prosthesis and in other parts, but also improving bone density around knee joint, lumbar spine and increasing HSS score of knee joint.
