Analysis for nosocomial infections in patients with induction period of acute leukemia
CHEN Yuemiao1, YU Kang2, ZHENG Cuiping1, HU Yingying1.
1.Department of Hematology, the Dingli Clinical Institute Affiliated to Wenzhou Medical University, Wenzhou Central Hospital, Wenzhou, 325000;2.Department of Hematology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015
CHEN Yuemiao,YU Kang,ZHENG Cuiping, et al. Analysis for nosocomial infections in patients with induction period of acute leukemia[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2016, 46(9): 676-679.
Abstract：Objective: To explore the clinical features and risk factors for nosocomial infection of patients with acute leukemia in induction period, so as to provide the theoretical basis for clinical intervention. Methods: One hundred and nine patients with acute leukemia in Wenzhou Central Hospital from February 2011 to September 2015 treated by remission induction chemotherapy were retrospectively analyzed to research the distribution of infection, pathogenic bacteria and risk factors for nosocomial infection. Results: The nosocomial infection rate of patients with acute leukemia in induction period was 71.56%, and the main part was the lower respiratory tract infection accounting for 27.72%. Gram negative bacilli were the major pathogens. The univariate analysis revealed that the incidence of nosocomial infection with acute leukemia in induction period was associated with age, leukemia type, neutrophil count, agranulocytosis time, days of hospitalization and chronic basic diseases (P<0.05); The multivariate logistic regression analysis indicated that age, neutrophil count, days of hospitalization and chronic basic disease were independent risk factors. Conclusion: Age, neutrophil count, days of hospitalization and chronic basic disease are independent risk factors for patients with acute leukemia in induction period, therefore efficacious protective steps should be taken against these factors.
