The influence of proton pump inhibitor on nutritional status in patients with post-stroke dysphagia
LYU Yanghui1, ZHOU Lin2, TANG Weiguo2.
1.Department of Neurology, Deqing People’s Hospital, Huzhou, 313200; 2.Department of Neurology, Zhoushan Hospital Affiliated to Wenzhou Medical University, Zhoushan, 316004
LYU Yanghui,ZHOU Lin,TANG Weiguo.. The influence of proton pump inhibitor on nutritional status in patients with post-stroke dysphagia[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2016, 46(9): 652-655.
Abstract：Objective: To explore the influence of proton pump inhibitor (PPI) on nutritional status in patients with post-stroke dysphagia. Methods: A total of 155 cerebral infarction patients with dysphagia were enrolled in this study. All the patients were given enteral nutrition by a gastric tube. Then they were randomly assigned into the PPI treatment group and the control group. Pantoprazole was given the PPI group to protect the gastric mucosa. The control group didn’t give any gastric mucosa protective treatment. Then the hemoglobin, serum albumin, triceps skinfold thickness, arm muscle circumference, gastric juice pH, NIHSS score, acute gastric mucosal lesions (AGML) and mortality rate were compared between the two groups. Results: The two groups had no significant difference in hemoglobin, serum albumin, triceps skinfold thickness, arm muscle circumference, gastric juice pH and NIHSS score on admission (P>0.05). After two weeks, the hemoglobin, serum albumin, triceps skinfold thickness, arm muscle circumference in two groups both decreased (P<0.05), and the PPI group decreased more compared to the control group (P<0.05). Also the PPI group had a lower NIHSS score (P<0.05) and lower risk of AGML (P<0.05). But the two groups had no significant difference in mortality rate (P>0.05). Conclusion: The using of PPI will influence the nutritional status in patients with post-stroke dysphagia. Using PPI has a poor neurological outcome, but has no relationship with mortality rate. In the protective treatment of gastric mucosa in cerebral infarction patients with dysphagia, the clinicians should weigh the risk of dystrophy. Then, an individualized treatment to each patient is given.
