1.Department of Endocrinology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015; 2.Department of Burns, the 118th Hospital of People’s Liberation Army, Wenzhou, 325001
GONG Xiaohua,WU Wenjun,CHEN Xiong, et al. Effects of diabetes on oxidative stress in burn wounds[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2016, 46(8): 597-599.
Abstract：Objective: To observe the metabolite level of oxidative stress in burned patients with or without type 2 diabetes mellitus, and to explore the relationship between oxidative stress and diabetic burned wounds. Methods: The patients were divided into 3 groups, including burned patients without DM (Burn group), burned patients with DM (DM-B group) and DM without burns. And another 21 healthy subjects were enrolled as control group. The levels of superoxide dismutase (SOD) and malondialdehyde (MDA) in plasma and wounds were detected. Results: The plasma levels of SOD in the DM-B group, Burn group and DM group were lower than that of the control group (P<0.05). The plasma concentrations of MDA were statistically significantly higher in the groups of DM-B, Burn and DM in comparison with the control group. The levels of SOD in the burn wounds were lower in DM-B group compared to Burn group on the 1st day following injury (P<0.05), which maintained until the 21st day. In DM-B group a statistically significant increase of the MDA was observed from the 1st day until the 21st day. Conclusion: These data show evidence of a marked,long-lasting oxidative stress in burned patients with DM compared to the burned patients without DM. For this reason, burned patients with DM are recommended to receive exogenous antioxidants.
