Expression and clinical roles of Survivin and EGFR in endometrial carcinoma
LIN Feng1, WANG Fang2, ZHOU Kai1.
1. Department of Gynecology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015; 2.Department of Pathology, the First Affiliated Hospital of Wenzhou Medical University,
Wenzhou, 325015
LIN Feng,WANG Fang,ZHOU Kai.. Expression and clinical roles of Survivin and EGFR in endometrial carcinoma[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2016, 46(8): 594-596.
Abstract：Objective: To investigate the expression of Survivin and EGFR in endometrial cancer tissues and to explore their relationship with histopathological grade, tumor stages, lymph node metastasis, etc. At last, the clinical roles of Survivin and EGFR in endometrial cancer were explored. Methods: The expressions of Survivin and EGFR were detected by immunohistochemical methods in the paraffin embedded sections of 71 endometrial cancer patients and the clinical data had been reviewed. Twenty normal endometrial tissues and 20 atypical hyperplasia endometrial tissues were chosen as control group. Results: Survivin and EGFR were over-expressed in 80.2% and 52.1% endometrial cancer specimens. The expression of Survivin was correlated to the histological grade and the expression of EGFR was correlated to the histological grade and overall survival. Over expression of Survivin and EGFR were correlated to each other. Conclusion: Both Survivin and EGFR were over-expressed in endometrial cancer specimens. Survivin and EGFR may play key roles in the development of endometrial cancer. Detection of the expression of Survivin and EGFR can be proposed in the evaluation of malignant degree and prognosis of endometrial cancer.
