Evaluation the anxiety behavior in different dosage of MPTP-induced Parkinson’s mice
YE Suzhen1, SHI Jian2, XIA Yu3, ZHANG Shuping4, HUANG Hanjin5.
1.Department of Rehabilitation Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015; 2.Department of Neurology, Mianyang Central Hospital, Mianyang, 621000; 3.Department of Emergency Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015; 4.Department of Neurology, Yueqing People’s Hospital, Wenzhou, 325600; 5.Department of Neurology, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325027
YE Suzhen,SHI Jian,XIA Yu, et al. Evaluation the anxiety behavior in different dosage of MPTP-induced Parkinson’s mice[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2016, 46(8): 586-589.
Abstract：Objective: To study the anxiety behavior in different dosage of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) -induced Parkinson’s mice. Methods: Forty C57BL/6J were randomly divided into 4 groups: Low-dose group (LG), moderate-dose group (DG), high-dose group (HG) and control group (CG). The anxiety behavior in mice was tested with the elevated plus-maze test and the light/dark box. Results: The time of stayed in the dark box of model groups mice were longer than those of the control group (P<0.05), but the time and transition among model groups mice had no difference (P>0.05). The OE, OT and OT% in mode groups mic were significant lower than that in the control group (P<0.05) in the elevated plus-maze test, but there was no significant difference among the three model groups (P>0.05). The OE% in LG and DG was lower than that in control group (P<0.05) in the elevated plus-maze test. Conclusion: Anxious behavior appears in the model groups of early PD mice. But there is no difference among those model groups. The anxiety behavior is not dose-dependent.
