YANG Fen,YAN Fang,WEI Lei, et al. IL-17 and IL-23 serum levels in patients undergoing colorectal cancer surgery: effects of different anesthetic techniques[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2016, 46(8): 578-581.
Abstract：Objective: To compare the effects of continuous epidural block combined with intravenous anesthesia, total intravenous anesthesia and total inhalational anesthesia on pro-inflammatory cytokines IL-17 and IL-23 serum levels in patients undergoing colorectal cancer surgery. Methods: All patients were randomly divided into three trials groups (n=20): continuous epidural block combined intravenous anesthesia group (A group): patients received continuous epidural anesthesia of bupivacaine, and received intravenous anesthesia with propofol; total intravenous anesthesia group (B group): patients received total intravenous anesthesia with propofol and fentanil; total inhalational anesthesia group (C group): patients received total inhalational anesthesia with sevoflurane in O2 and Nitrous Oxide. Control group was composed of healthy subjects. Serum levels of IL-17 and IL-23 were quantified. Results: In three trials groups, levels of IL-17 and IL-23 were high prior to control group at induction of anesthesia (T0), and there was no difference between three groups (P>0.05). Compared with T0, levels of IL-17 and IL-23 significantly decreased at 60 min after the start of surgery (T1), 30 min post-surgery (T2) and 24 h post-surgery (T3); Levels of IL-17 and IL-23 were significantly lower at T1 than T2 and T3, and they were significantly lower at T2 than T3 (P<0.05). At T1 and T2, levels of IL-17 and IL-23 were significantly lower in A group than that in B group, and they were significantly lower in B group than C group (P<0.05); there was no difference between three trials groups at 24 h post-surgery (P>0.05). Conclusion: Three anesthetic techniques significantly decreases IL-17 and IL-23 levels, so they has inhibiting effect on colorectal cancer. In this respect, continuous epidural block combined with intravenous anesthesia is better than the other two, total intravenous anesthesia is better than total inhalational anesthesia.
