Prediction of subacute infarct lesion volume in hyperacute cerebral artery stroke: comparison of perfusion-weighted imaging and apparent diffusion coefficient maps
SHAO Xiaotong1,2, GUO Xianzhong1, CHEN Weijian1, WANG Hao1, LIN Boli1, XIA Nengzhi1, YANG Yunjun1.
1.Department of Radiology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015; 2.Department of Radiology, the Second Affiliated Hospital of School of Medicine, Zhejiang University, Hangzhou, 310000
SHAO Xiaotong,GUO Xianzhong,CHEN Weijian, et al. Prediction of subacute infarct lesion volume in hyperacute cerebral artery stroke: comparison of perfusion-weighted imaging and apparent diffusion coefficient maps[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2016, 46(8): 566-570.
Abstract：Objective: To compare perfusion-weighted imaging (PWI) and apparent diffusion coefficient (ADC) maps in prediction of infarct lesion volumes and growth in patient with hyperacute cerebral artery infarct. Methods: Twenty hyperacute cerebral artery stroke patients who underwent multimodal magnetic resonance imaging (MRI) in hyperacute (<6 h) phase and the follow-up MRI in the subacute (days 5-7) phase were retrospectively reviewed. Diffusion- and perfusion-weighted imaging lesion volumes were semi-automatically measured by a post-processing software of GE Healthcare 3.0 T MR scanner (Signa Twin Speed, GE Medical System, Milwaukee, Wisconsin, USA). Finally, to compare the two methods in infarct growth prediction, correlation and regression analysis and receiver operating characteristic curves were used. Results: The lesion volume of follow-up FLAIR was highly correlated with volumes predicted with ADC-, CBF-, CBV-, MTT-, and TTP-maps (all P<0.05). The correlation was higher for ADC-predicted volume (r=0.954, 95%CI: 0.804-1.000) than that for PWI- predicted volume (P<0.05). Besides, The infarct growth was correlated with ADC-DWI mismatch (r=0.744, P=0.001), but we didn’t find any correlation among infarct growth and CBF-DWI, CBV-DWI, MTT-DWI, TTP-DWI mismatches (all P>0.05). Conclusion: Data showed that by using the post-processing software provided by MR equipment, the ADC-based method is more feasible than PWI-based method for evaluating infarct growth and volume in the subacute phase, which makes early estimation of prognosis possible.
